Evidence map›Paper›PMID 29557528›Full record

Observational studyJournal of anesthesia2018

Intraoperative red blood cell transfusion, delayed graft function, and infection after kidney transplant: an observational cohort study.

Michael Mazzeffi, Srikar Jonna, Natalia Blanco, Orestes Mavrothalassitis, Obi Odekwu, Magali Fontaine, Peter Rock, Kenichi Tanaka, Kerri Thom

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of anesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michael MazzeffiUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA. mmazzeffi@som.umaryland.edu.ORCID 0000-0003-2955-4915
Srikar JonnaUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Natalia BlancoUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Orestes MavrothalassitisUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Obi OdekwuUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Magali FontaineUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Peter RockUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Kenichi TanakaUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
Kerri ThomUniversity of Maryland School of Medicine, 22 South Greene Street S11C00, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplant patients are frequently anemic and at risk for red blood cell (RBC) transfusion. Previous studies suggest that pre-transplant RBC transfusion may improve kidney transplant outcomes; however, RBC transfusion is also associated with infection. The purpose of our study was to characterize the relationships between intraoperative RBC transfusion, delayed graft function (DGF), postoperative surgical site infection (SSI), and sepsis.

methodsAnalysis was performed on a historical cohort of adult kidney transplant patients from a single medical center during a two-year period. Crude odds ratios for DGF, superficial and deep SSI, and sepsis were calculated for transfused patients and multivariate regression was used to control for potential confounders when significant relationships were identified.

resultsFour hundred forty-one patients had kidney transplant during the study period; 27.0% had RBC transfusion, 38.8% had DGF, 7.0% had superficial SSI, 7.9% had deep SSI, and 1.8% had sepsis. High dose RBC transfusion was associated with improved graft function, but this was negated after adjusting for confounders (OR = 0.86, 95% CI  0.26 to 2.88). There was no association between RBC transfusion and SSI. RBC transfusion was independently associated with sepsis (OR = 8.98, 95% CI  1.52 to 53.22), but the confidence interval was wide.

conclusionsIntraoperative RBC transfusion during kidney transplant is not associated with improved allograft function or incisional SSI, but is associated with postoperative sepsis. RBCs should not be liberally transfused during kidney transplant surgery to improve graft outcomes.

Indexed as

AdultBlood Loss, SurgicalCohort StudiesDelayed Graft FunctionErythrocyte TransfusionFemaleHumansKidney TransplantationMaleOdds RatioSurgical Wound InfectionInfectionKidney transplantSepsisTransfusion

Identifiers

PMID29557528
OpenAlexW2790085797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.