Evidence map›Paper›PMID 29557216›Full record

ArticleThe British journal of radiology2018

Fully automated segmentation and quantification of visceral and subcutaneous fat at abdominal CT: application to a longitudinal adult screening cohort.

Scott J Lee, Jiamin Liu, Jianhua Yao, Andrew Kanarek, Ronald M Summers, Perry J Pickhardt

Abstract read
In one paragraph

Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Precision or Paradox? AI-Driven Adiposity Imaging in Women With Overweight and Obesity: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  2. Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Article
  3. Article
  4. Article
  5. Optimizing CT-Based Models for Predicting Whole-Body Fat in Rabbits.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
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  7. Article
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  13. Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Scott J Lee1 Department of Radiology, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA.
Jiamin Liu2 Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health Clinical Center , Bethesda, MD , USA.
Jianhua Yao2 Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health Clinical Center , Bethesda, MD , USA.
Andrew Kanarek1 Department of Radiology, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA.
Ronald M Summers2 Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, National Institutes of Health Clinical Center , Bethesda, MD , USA.
Perry J Pickhardt1 Department of Radiology, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA.

Funding

Computer Aided Detection for CT ColonographyZIACL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
Computer Aided Detection for Radiologic ImagesZIACL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
6 · The paper itself

Abstract

objectiveTo investigate a fully automated CT-based adiposity tool, applying it to a longitudinal adult screening cohort.

methodsA validated automated adipose tissue segmentation algorithm was applied to non-contrast abdominal CT scans in 8852 consecutive asymptomatic adults (mean age, 57.1 years; 3926 M/4926 F) undergoing colonography screening. The tool was also applied to follow-up CT scans in a subset of 1584 individuals undergoing longitudinal surveillance (mean interval, 5.6 years). Visceral and subcutaneous adipose tissue (VAT and SAT) volumes were segmented at levels T12-L5. Primary adipose results are reported herein for the L1 level as mean cross-sectional area. CT-based adipose measurements at initial CT and change over time were analyzed.

resultsMean VAT values were significantly higher in males (205.8 ± 107.5 vs 108.1 ± 82.4 cm

conclusionThis robust, fully automated CT adiposity tool allows for both individualized and population-based assessment of visceral and subcutaneous abdominal fat. Such data could be automatically derived at abdominal CT regardless of the study indication, potentially allowing for opportunistic cardiovascular risk stratification. Advances in knowledge: The CT-based adiposity tool described herein allows for fully automated measurement of visceral and subcutaneous abdominal fat, which can be used for assessing cardiovascular risk, metabolic syndrome, and for change over time.

Indexed as

AlgorithmsTomography, X-Ray ComputedAdultColonFemaleHumansIntra-Abdominal FatMaleMiddle AgedRadiography, AbdominalRetrospective StudiesSubcutaneous Fat

Identifiers

PMID29557216
PMCPMC6223139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.