Evidence map›Paper›PMID 29556924›Full record

ArticleMolecular diagnosis & therapy2018

Decreased Expression of Circulating miR-20a-5p in South African Women with Gestational Diabetes Mellitus.

Carmen Pheiffer, Stephanie Dias, Paul Rheeder, Sumaiya Adam

Abstract read
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In one paragraph

Article in Molecular diagnosis & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  12. Pancreatic MicroRNAs inBiomolecules · 2025
    Article
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  18. Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carmen PheifferBiomedical Research and Innovation Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town, 7505, South Africa. carmen.pheiffer@mrc.ac.za.ORCID http://orcid.org/0000-0002-0707-1552
Stephanie DiasBiomedical Research and Innovation Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town, 7505, South Africa.
Paul RheederDepartment of Internal Medicine, University of Pretoria, Private Bag X169, Pretoria, 0001, South Africa.
Sumaiya AdamDepartment of Obstetrics and Gynaecology, University of Pretoria, Private Bag X169, Pretoria, 0001, South Africa.
South African Medical Research Council · ZAUniversity of Pretoria · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveIn recent years circulating microRNAs (miRNAs) have attracted interest as biomarkers of metabolic disease. MiRNA expression varies across population groups; thus, the aim of this study was to investigate whether serum miRNAs that have previously been shown to be associated with gestational diabetes mellitus (GDM) in other populations, are similarly regulated in South African women with GDM.

methodsIn this case-control study, women (n = 81) were selected from a prospective cohort study in which pregnant women were recruited at their first clinic visit and requested to return for fasting blood glucose concentration measurements and serum collection (median 27 weeks; range 13-31 weeks). The expression of miR-16-5p, miR-17-5p, miR-19a-3p, miR-19b-3p, miR-20a-5p, miR-29a-3p, miR-132-3p, and miR-222-3p was quantified using miScript

resultsMiR-20a-5p (2.7-fold decrease; p = 0.038) and miR-222-3p (2.6-fold decrease; p = 0.027) were significantly decreased in women with GDM compared with controls. Logistic regression showed that miR-20a-5p and one or more risk factor are significant predictors of GDM. Functional assessment using DIANA-miRPath v3.0 revealed that miR-20a-5p controls various metabolic pathways, including insulin signaling. DISCUSSION: This study identifies miR-20a-5p as a potential biomarker for GDM in our population. Gene targets of miR-20a-5p regulate a number of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways not related to GDM, suggesting that miR-20a-5p may have limited disease specificity on its own. Such miRNAs may be useful if incorporated into miRNA panels or risk assessment algorithms to identify GDM. Studies with larger samples are required to strengthen the candidacy of miR-20a-5p as a biomarker for GDM and to assess clinical applicability.

Indexed as

Gene Expression RegulationAdolescentAdultBiomarkersBlack PeopleCase-Control StudiesDiabetes, GestationalFemaleGene Expression ProfilingHumansLogistic ModelsMetabolic Networks and PathwaysMicroRNAsPregnancyProspective StudiesRisk FactorsBiomarkersMicroRNAsMIRN20a microRNA, human

Identifiers

PMID29556924
OpenAlexW2793485880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.