ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2018
Cannabis Addiction and the Brain: a Review.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07638189 (Pilot Study Using Topical Cannabidiol), which is not on this map. Cited by 124 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain
Who cites it
124 citing papers in PubMed, 7 syntheses or guidelines pooled it, 237 citations in OpenAlex.
- Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls: A systematic review of diffusion-weighted MRI studies.Frontiers in neuroimaging · 2023Pooled it
- Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder.Frontiers in psychiatry · 2023Pooled it
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- Cannabinoids in the Treatment of Cannabis Use Disorder: Systematic Review of Randomized Controlled Trials.Frontiers in psychiatry · 2022Pooled it
- Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users: a systematic review of fMRI studies.Psychopharmacology · 2021Pooled it
- Role of microRNAs in the pathophysiology of addiction.Wiley interdisciplinary reviews. RNA · 2021Pooled it
- Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study.Translational psychiatry · 2020Trial
- The Cannabis Research Image Database (CRESIDA): A standardized and validated image set for studying cannabis cue reactivity.Addiction (Abingdon, England) · 2026Article
- The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Increased encoding of aversive stimuli by lateral habenula neurons during ΔNature communications · 2026Article
- Characterizing public comments via Regulations.gov in response to proposed cannabis rescheduling in the United States.Addiction (Abingdon, England) · 2026Article
- Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cannabis use and beliefs among people in recovery from substance use disorders.Journal of cannabis research · 2026Article
- No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups.Psychopharmacology · 2026Article
- Associations of cannabis, alcohol, and tobacco use combinations with sleep health.Addictive behaviors reports · 2026Article
- Problematic social media use among recreational cannabis users in Québec: A Cross-Sectional study.Addictive behaviors reports · 2026Article
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
- Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain.Scientific reports · 2026Article
- Novel pharmacotherapies for opioid use disorder and opioid withdrawal.Frontiers in psychiatry · 2026Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cannabis is the most commonly used substance of abuse in the United States after alcohol and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a decrease in the perceived risk of cannabis use, it is imperative to assess the addictive potential of cannabis. Here we evaluate cannabis use through the neurobiological model of addiction proposed by Koob and Volkow. The model proposes that repeated substance abuse drives neurobiological changes in the brain that can be separated into three distinct stages, each of which perpetuates the cycle of addiction. Here we review previous research on the acute and long-term effects of cannabis use on the brain and behavior, and find that the three-stage framework of addiction applies to CUD in a manner similar to other drugs of abuse, albeit with some slight differences. These findings highlight the urgent need to conduct research that elucidates specific neurobiological changes associated with CUD in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.