ReviewPharmaceutical research2018
Influences of Crystal Anisotropy in Pharmaceutical Process Development.
Review in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Hydrodynamically decoupled nanoprecipitation (HDNP): A multi-stage strategy for supersaturation, controlled delayed nucleation, and stabilization of low LogP poorly-water soluble drugs.International journal of pharmaceutics: X · 2026Article
- Assessing crystallisation behaviour in molecular crystals through particle rugosities.Communications chemistry · 2026Article
- 3D Printing of Hydrophobic API-Infused Alginate-Gelatin Porous Scaffolds Reinforced with TiOACS omega · 2026Article
- Application of Amorphous Nanomaterials in Dentistry: A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Enhancing the solubility of celecoxib via lyophilized solid dispersions using computational and experimental approaches.Scientific reports · 2025Article
- Solid-Liquid Interfacial Free Energy from Computer Simulations: Challenges and Recent Advances.Chemical reviews · 2025Review
- Process-Induced Crystal Surface Anisotropy and the Impact on the Powder Properties of Odanacatib.Pharmaceutics · 2024Article
- Characterization of Mass Transfer within the Crystal-Solution Boundary Layer of l-Alanine {120} Faces Using Laser Interferometry during Growth and Dissolution.Crystal growth & design · 2023Article
- Designer Gelators for the Crystallization of a Salt Active Pharmaceutical Ingredient-Mexiletine Hydrochloride.Crystal growth & design · 2022Article
- Relating Crystal Structure to Surface Properties: A Study on Quercetin Solid Forms.Crystal growth & design · 2022Article
- Space Medicines for Space Health.ACS medicinal chemistry letters · 2022Article
- A Digital Mechanistic Workflow for Predicting Solvent-Mediated Crystal Morphology: The α and β Forms of l-Glutamic Acid.Crystal growth & design · 2022Article
- Exploring the role of crystal habit in the Ostwald rule of stages.Proceedings. Mathematical, physical, and engineering sciences · 2022Article
- Article
- Τhe role of surface energy in the apparent solubility of two different calcite crystal habits.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- Periodic DFT Calculations-Review of Applications in the Pharmaceutical Sciences.Pharmaceutics · 2020Review
- Formulation and Manufacturing of Solid Dosage Forms.Pharmaceutical research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crystalline materials are of crucial importance to the pharmaceutical industry, as a large number of APIs are formulated in crystalline form, occasionally in the presence of crystalline excipients. Owing to their multifaceted character, crystals were found to have strongly anisotropic properties. In fact, anisotropic properties were found to be quite important for a number of processes including milling, granulation and tableting. An understanding of crystal anisotropy and an ability to control and predict crystal anisotropy are mostly subjects of interest for researchers. A number of studies dealing with the aforementioned phenomena are grounded on over-simplistic assumptions, neglecting key attributes of crystalline materials, most importantly the anisotropic nature of a number of their properties. Moreover, concepts such as the influence of interfacial phenomena in the behaviour of crystalline materials during their growth and in vivo, are still poorly understood. The review aims to address concepts from a molecular perspective, focusing on crystal growth and dissolution. It begins with a brief outline of fundamental concepts of intermolecular and interfacial phenomena. The second part discusses their relevance to the field of pharmaceutical crystal growth and dissolution. Particular emphasis is given to works dealing with mechanistic understandings of the influence of solvents and additives on crystal habit. Furthermore, comments and perspectives, highlighting future directions for the implementation of fundamental concepts of interfacial phenomena in the rational understanding of crystal growth and dissolution processes, have been provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.