Evidence map›Paper›PMID 29556684›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2018

Phosphodiesterase PDE2 activity, increased by isoprenaline, does not reduce β-adrenoceptor-mediated chronotropic and inotropic effects in rat heart.

Alejandro Galindo-Tovar, María Luisa Vargas, Alberto J Kaumann

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Which phosphodiesterase can decrease cardiac effects of 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alejandro Galindo-TovarGrado en Farmacia, Facultad Ciencias de la Salud, Universidad Católica San Antonio de Murcia, 30107, Murcia, Spain.
María Luisa VargasDepartamento de Farmacología, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain.
Alberto J KaumannDepartamento de Farmacología, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain. kaumann@um.es.
Universidad de Murcia · ESUniversidad Católica San Antonio de Murcia · ES

Funding

Ministerio de Ciencia e Innovación SAF/FEDER 2013-47076Universidad Católica San Antonio de Murcia PMAFI/07/14
6 · The paper itself

Abstract

Myocardial PDE2 activity increases in terminal human heart failure and after isoprenaline infusion in rat heart. PDE2 inhibitors do not potentiate the murine sinoatrial tachycardia produced by noradrenaline. We investigated whether isoprenaline infusion induces PDE2 to decrease the chronotropic and inotropic effects of catecholamines in rat heart. Sprague-Dawley rats were infused with isoprenaline (2.4 mg kg

Indexed as

Adrenergic beta-AgonistsAnimalsCardiotonic AgentsCyclic Nucleotide Phosphodiesterases, Type 2EpinephrineHeartIn Vitro TechniquesIsoproterenolMaleNorepinephrineRats, Sprague-DawleyReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2TachycardiaAdrenergic beta-AgonistsCardiotonic AgentsCyclic Nucleotide Phosphodiesterases, Type 2EpinephrineIsoproterenolNorepinephrineReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2AdrenalineNoradrenalinePhosphodiesterase2Sinoatrial tachycardiaVentricular force

Identifiers

PMID29556684
OpenAlexW2791883799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.