ArticleInternational urogynecology journal2018
Recalcitrant chronic bladder pain and recurrent cystitis but negative urinalysis: What should we do?
Article in International urogynecology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- What is chronic urinary tract infection? A systematic review.BJU international · 2025Pooled it
- Circulating Neutrophils Exhibit an Altered Immune Response in Chronic LUTS: An Image-Based Deep Learning Analysis.International urogynecology journal · 2026Article
- Outcomes of Long-Term Antibiotic Therapy in Women with Chronic Recalcitrant Cystitis.International urogynecology journal · 2026Article
- The Vaginal Microbiome and Recurrent and Chronic Urinary Tract Infection.International urogynecology journal · 2026Review
- Rethinking urinary tract infections in women with abdominal pain in pregnancy: a prospective case-control study.BMC pregnancy and childbirth · 2026Observational
- From Dismissal to Partnership: Patient Experiences of Recurrent Urinary Tract Infection Healthcare Informed by the Theoretical Domains Framework and Behaviour Change Theory.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- The natural immune molecules urinary Tamm-Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study.Renal failure · 2025Article
- Long-Term Antibiotics for Disturbed Bladder Microbiome Disorders.International urogynecology journal · 2025Review
- Antibiotic therapy for treating overactive bladder is not supported by clinical evidence.Nature reviews. Urology · 2025Review
- Novel Techniques to Unravel Causative Bacterial Ecological Shifts in Chronic Urinary Tract Infection.Pathogens (Basel, Switzerland) · 2025Article
- Detection of Bacteria in Bladder Mucosa of Adult Females.The Journal of urology · 2023Article
- Changes of microbiota level in urinary tract infections: A meta-analysis.Open medicine (Warsaw, Poland) · 2023Article
- Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens.Research and reports in urology · 2023Article
- Women's Experiences of Interstitial Cystitis/Painful Bladder Syndrome.Western journal of nursing research · 2022Article
- A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome.BMC urology · 2021Observational
- Urinary Microbiome Characteristics in Female Patients with Acute Uncomplicated Cystitis and Recurrent Cystitis.Journal of clinical medicine · 2021Article
- A revalidation and critique of assumptions about urinary sample collection methods, specimen quality and contamination.International urogynecology journal · 2020Article
- Cross-over data supporting long-term antibiotic treatment in patients with painful lower urinary tract symptoms, pyuria and negative urinalysis.International urogynecology journal · 2019Article
- Reassessment of Routine Midstream Culture in Diagnosis of Urinary Tract Infection.Journal of clinical microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLower urinary tract symptoms (LUTS) may be associated with chronic urinary tract infection (UTI) undetected by routine diagnostic tests. Antimicrobial therapy might confer benefit for these patients. MATERIALS AND
methodsOver 10 years, we treated patients with chronic LUTS. Pyuria was adopted as the principal biomarker of infection. Urinary leucocyte counts were recorded from microscopy of fresh midstream urine (MSU) samples. Antibiotics were prescribed and the prescription adjusted to achieve a measurable clinical response and a reduction in pyuria.
resultsWe treated 624 women [mean age = 53.4 years; standard deviation (SD) = 18] with chronic LUTS and pyuria. Mean duration of symptoms prior to presentation was 6.5 years. Only 16% of MSU cultures submitted were positive (≥10
conclusionThis large case series demonstrates that patients with chronic LUTS and pyuria experience symptom regression and a reduction in urinary tract inflammation associated with antimicrobial therapy. Disease regression was achieved with a low frequency of AEs. These results provide preliminary data to inform a future randomized controlled trial (RCT).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.