ArticlemSystems
Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease.
Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement.Nature cardiovascular research · 2026Article
- Widespread effects of catecholamines on growth of human gut bacteria.NPJ biofilms and microbiomes · 2026Article
- Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection.Nature microbiology · 2026Article
- Article
- AI digital-twin ecosystem translating gut-microbiome-neuroimmune signals into precision sleep-mood interventions.Frontiers in psychiatry · 2026Review
- Targeting the Microbiota Reverses C-Section-Induced Effects on Intestinal Permeability, Microbiota Composition, and Amygdala Gene Expression in the Mouse.Neurogastroenterology and motility · 2025Article
- Protein language models uncover carbohydrate-active enzyme function in metagenomics.BMC bioinformatics · 2025Article
- Microbiota Dysbiosis inMicroorganisms · 2025Article
- Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases.Journal of personalized medicine · 2024Review
- Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.Frontiers in immunology · 2022Review
- Ecological Dynamics and Microbial Treatments against Oomycete Plant Pathogens.Plants (Basel, Switzerland) · 2021Review
- Natural experiments and long-term monitoring are critical to understand and predict marine host-microbe ecology and evolution.PLoS biology · 2021Article
- Functional lower airways genomic profiling of the microbiome to capture active microbial metabolism.The European respiratory journal · 2021Article
- The microbiome and its impact on food allergy and atopic dermatitis in children.Postepy dermatologii i alergologii · 2020Review
- Every fifth published metagenome is not available to science.PLoS biology · 2020Article
- Trends in the Immunomodulatory Effects ofFrontiers in pharmacology · 2020Review
- From the raw bar to the bench: Bivalves as models for human health.Developmental and comparative immunology · 2019Review
- Visualizing microbiome-immune system interplay.Immunotherapy · 2019Article
- Caries-associated oral microbiome in head and neck cancer radiation patients: a longitudinal study.Journal of oral microbiology · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In recent years, there has been a deluge of papers linking altered microbiome compositions to a myriad of diseases. Mechanistic insight into microbial drivers of disease phenotypes is essential for translation to novel therapies. A key mechanism by which microbes influence health is immune modulation by components of their capsule and cell envelope and their metabolites. A major research focus of my laboratory is to gain mechanistic insight into which microbes modulate host immunity generally and in the context of disease. Using 16S rRNA-targeted sequencing, we have established associations between gut microbiome composition and immune-modulated disease phenotypes in diseases such as graft-versus-host disease in cancer patients undergoing stem cell transplantation. By integrating omics and computational approaches with laboratory experiments, we have expanded knowledge of mechanisms used by host-associated microbes to dampen inflammatory responses. This work has promise for development of novel microbiome-targeted therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.