ArticleFrontiers in veterinary science2018
The Unexplored Role of Intra-articular Adipose Tissue in the Homeostasis and Pathology of Articular Joints.
Article in Frontiers in veterinary science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Motion as Medicine: Physical Activity, Joint Sensitivity, and Pain Management-A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Pulvinar signal abnormalities on MRI are associated with atraumatic hip pain.Skeletal radiology · 2026Article
- Statin-Mediated Modulation of Nrf2 Signaling: Mechanisms and Therapeutic Implications in Atherosclerosis.Reviews in cardiovascular medicine · 2026Review
- Next-generation osteoarthritis models: integrating biological, computational, and engineering approaches.Stem cell research & therapy · 2025Review
- Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis.Arthritis research & therapy · 2025Review
- Anatomy, Histology, and Embryonic Origin of Adipose Tissue: Insights to Understand Adipose Tissue Homofunctionality in Regeneration and Therapies.Advances in experimental medicine and biology · 2025Review
- Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management.Biomedicines · 2024Review
- Article
- Senescence in Osteoarthritis: Overview of Mechanisms and Therapeutics.European journal of rheumatology · 2023Article
- Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon.Bone & joint research · 2022Article
- Joint-on-chip platforms: entering a new era of in vitro models for arthritis.Nature reviews. Rheumatology · 2022Review
- Impact of body composition analysis on male sexual function: A metabolic age study.Frontiers in endocrinology · 2022Article
- Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity?Journal of orthopaedic translation · 2022Review
- Stem Cells in Autologous Microfragmented Adipose Tissue: Current Perspectives in Osteoarthritis Disease.International journal of molecular sciences · 2021Review
- Hip preservation surgery and the acetabular fossa.Bone & joint research · 2020Article
- Assessment and Comparison of the Efficacy of Methotrexate, Prednisolone, Adalimumab, and Tocilizumab on Multipotency of Mesenchymal Stem Cells.Frontiers in pharmacology · 2020Article
- Quantification of fat in the posterior sacroiliac joint region: fat volume is sex and age dependant.Scientific reports · 2019Article
- Computational deconvolution of synovial tissue cellular composition: presence of adipocytes in synovial tissue decreased during arthritis pathogenesis and progression.Physiological genomics · 2019Article
- Different Secretory Activity of Articular and Subcutaneous Adipose Tissues from Rheumatoid Arthritis and Osteoarthritis Patients.Inflammation · 2019Article
- Explant models for meniscus metabolism, injury, repair, and healing.Connective tissue researchReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-articular adipose tissue deposits known as articular fat pads (AFPs) are described to exist within synovial joints. Their assumed role in normal joint biomechanics is increasingly objectivized by means of advanced methods of functional imaging. AFPs possess structural similarity with body subcutaneous white adipose tissue (WAT), however, seems to be regulated by independent metabolic loops. AFP dimension are conserved during extreme WAT states: obesity, metabolic syndrome, lipodystrophy, and cachexia. Hoffa fat pad (HFP) in the knee is increasingly recognized as a major player in pathological joint states such as anterior knee pain and osteoarthritis. HFP contains numerous population of mesenchymal and endothelial progenitors; however, the possible role of mature adipocytes in the maintenance of stem cell niche is unknown. We propose that AFP is an active component of the joint organ with multifunctional roles in the maintenance of joint homeostasis. Endowed with a rich network of sensitive nervous fibbers, AFPs may act as a proprioceptive organ. Adipokines and growth factors released by AFP-resident mature adipocytes could participate in the maintenance of progenitor stem cell niche as well as in local immune regulation. AFP metabolism may be locally controlled, correlated with but independent of WAT homeostasis. The identification of AFP role in normal joint turnover and its possible implication in pathological states could deliver diagnostic and therapeutic targets. Drug and/or cell therapies that restore AFP structure and function could become the next step in the design of disease modifying therapies for disabling joint conditions such as osteoarthritis and inflammatory arthritis.
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