Evidence map›Paper›PMID 29556413›Full record

ArticlePorcine health management2018

Effect of oral KETOPROFEN treatment in acute respiratory disease outbreaks in finishing pigs.

Outi Hälli, Minna Haimi-Hakala, Tapio Laurila, Claudio Oliviero, Elina Viitasaari, Toomas Orro, Olli Peltoniemi, Mika Scheinin, Saija Sirén, Anna Valros and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Porcine health management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Outi Hälli1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.ORCID 0000-0002-0134-7888
Minna Haimi-Hakala1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
Tapio Laurila1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
Claudio Oliviero1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
Elina Viitasaari1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
Toomas Orro2Department of Clinical Veterinary Medicine, Estonian University of Life Sciences, Kreutzwaldi 62, 51014 Tartu, EE Estonia.
Olli Peltoniemi1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
Mika ScheininInstitute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University Hospital, 20014 Turku, FI Finland.
Saija SirénInstitute of Biomedicine, University of Turku, and Unit of Clinical Pharmacology, Turku University Hospital, 20014 Turku, FI Finland.
Anna Valros3Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, FI Finland.
Mari Heinonen1Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920 Saarentaus, FI Finland.
University of Helsinki · FIUniversity of Turku · FIEstonian University of Life Sciences · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effects of oral NSAID medication given in feed in acute outbreaks of respiratory disease in finishing pigs. The short- and long-term impact of NSAID dosing on clinical signs, daily weight gain, blood parameters and behaviour of growing pigs in herds with acute respiratory infections were evaluated. Four finishing pig farms suffering from acute outbreaks of respiratory disease were visited thrice after outbreak onset (DAY 0, DAY 3 and DAY 30). Pigs with the most severe clinical signs (

resultsCompared to the placebo treatment, dosing of ketoprofen reduced sickness behaviour and lowered the rectal temperature of the pigs. Clinical signs, feed intake or blood parameters were not different between the treatment groups. Ketoprofen treatment was associated with somewhat reduced weight gain over the 30-day follow-up period. Concentration analysis of the

conclusionsKetoprofen mainly influenced the behaviour of the pigs, while it had no effect on recovery from respiratory clinical signs. However, the medication may have been started after the most severe clinical phase of the respiratory disease was over, and this delay might complicate the evaluation of treatment effects. Possible negative impact of ketoprofen on production parameters requires further evaluation.

Indexed as

Actinobacillus pleuropneumoniaeAcute phase proteinsBehaviourDaily weight gainNSAIDPer os medication

Identifiers

PMID29556413
PMCPMC5838944
OpenAlexW2793868788

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.