Evidence map›Paper›PMID 29556356›Full record

ArticleTheranostics2018

Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.

Jeffrey R Ashton, Katherine D Castle, Yi Qi, David G Kirsch, Jennifer L West, Cristian T Badea

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Ultrasmall Bi/BiNanoscale advances · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Contrast-enhanced photon-counting micro-CT of tumor xenograft models.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Iodine Nanoparticles (NiodxPharmaceutics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jeffrey R AshtonCenter for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC 27710, United States.
Katherine D CastleDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27705, United States.
Yi QiCenter for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC 27710, United States.
David G KirschDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27705, United States.
Jennifer L WestDepartment of Biomedical Engineering, Duke University, Durham, NC, 27705, United States.
Cristian T BadeaCenter for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC 27710, United States.
Duke University · USDuke Medical Center · USDuke University Hospital · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
The Duke Preclinical Research Resources for Quantitative Imaging BiomarkersU24CA220245 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2017 to 2021
$2.8M
Development of a New Generation Micro-CT imaging for Functional and Molecular Imaging of CancerR01CA196667 · NCI · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2015 to 2019
$2.3M
An Activatable Nanoparticle Probe for Molecular Imaging of Protease Activity by Dual Energy CTF30EB020512 · NIBIB · DUKE UNIVERSITY · PI ASHTON, JEFFREY R · 2015 to 2017
$115k
NCI NIH HHS R01 CA196667NCI NIH HHS R35 CA197616NCI NIH HHS U24 CA220245NIBIB NIH HHS F30 EB020512NIBIB NIH HHS P41 EB015897NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently release low-energy, short-range photoelectrons during external beam radiation therapy (RT), increasing the local radiation dose. When AuNPs are near tumor vasculature, the additional radiation dose can lead to increased vascular permeability. This work focuses on understanding how tumor vascular permeability is influenced by AuNP-augmented RT, and how this effect can be used to improve the delivery of nanoparticle chemotherapeutics.

Indexed as

AnimalsAntineoplastic AgentsBlood VesselsDoxorubicinGoldIodineLiposomesMetal NanoparticlesMiceOligopeptidesPermeabilitySarcomaSarcoma, ExperimentalTomography, X-Ray ComputedTreatment OutcomeAntineoplastic Agentsarginyl-glycyl-aspartic acidDoxorubicinGoldIodineLiposomesOligopeptidesdual-energy CTnanoparticlesradiation therapysmall animal imagingtumor drug deliveryvascular imaging

Identifiers

PMID29556356
PMCPMC5858500
OpenAlexW2789019692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.