Evidence map›Paper›PMID 29556344›Full record

ArticleTheranostics2018

Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis.

Chun-Yuan Chen, Shan-Shan Rao, Lu Ren, Xiong-Ke Hu, Yi-Juan Tan, Yin Hu, Juan Luo, Yi-Wei Liu, Hao Yin, Jie Huang and 7 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
225citing papers in PubMed, 6 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

225 citing papers in PubMed, 6 syntheses or guidelines pooled it, 376 citations in OpenAlex.

  1. Pooled it
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  5. Role of Exosomes in Dermal Wound Healing: A Systematic Review.The Journal of investigative dermatology · 2022
    Pooled it
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  7. Review
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  11. Article
  12. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
    Review
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165 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Chun-Yuan ChenMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Shan-Shan RaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Lu RenXiangya Nursing School, Central South University, Changsha, Hunan 410013, China.
Xiong-Ke HuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yi-Juan TanMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yin HuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Juan LuoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yi-Wei LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Hao YinMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jie HuangMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jia CaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhen-Xing WangMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zheng-Zhao LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Hao-Ming LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Si-Yuan TangXiangya Nursing School, Central South University, Changsha, Hunan 410013, China.
Ran XuSecond Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Hui XieMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Xiangya Hospital Central South University · CNCentral South University · CNHunan University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic non-healing wounds represent one of the most common complications of diabetes and need advanced treatment strategies. Exosomes are key mediators of cell paracrine action and can be directly utilized as therapeutic agents for tissue repair and regeneration. Here, we explored the effects of exosomes from human urine-derived stem cells (USC-Exos) on diabetic wound healing and the underlying mechanism.

Indexed as

AdipocytesAnimalsAntigens, CDCalcium-Binding ProteinsCell DifferentiationCell MovementCell ProliferationChondrocytesCulture Media, ConditionedDiabetes Mellitus, ExperimentalDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportEndothelial CellsExosomesFemaleGene ExpressionAntigens, CDCalcium-Binding ProteinsCulture Media, ConditionedDMBT1 protein, humanDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportReceptors, Cell SurfaceStreptozocinTranscription FactorsTsg101 ProteinTumor Suppressor Proteinsangiogenesischronic woundDMBT1exosomesurine-derived stem cells

Identifiers

PMID29556344
PMCPMC5858170
OpenAlexW2790987851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.