Evidence map›Paper›PMID 29556335›Full record

Trial reportTheranostics2018

Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet.

Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu and 5 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Human plasma metabolomics reveals metabolic targets for intervention in salt-sensitive hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Amino acid metabolism in kidney health and disease.Nature reviews. Nephrology · 2024
    Review
  7. Blood L-cystine levels positively related to increased risk of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Metabolomics study of blood pressure salt-sensitivity and hypertension.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022
    Article
  13. Article
  14. Cysteine as a Multifaceted Player in Kidney, theMolecules (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Renal metabolism and hypertension.Nature communications · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Yuan ChengDepartment of Nephrology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Clinical Institute of Anhui Medical University, Shenzhen, Guangdong, P.R. China.
Haiying SongDepartment of Nephrology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Clinical Institute of Anhui Medical University, Shenzhen, Guangdong, P.R. China.
Xiaoqing PanCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hong XueCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yifei WanCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Tao WangDivision of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
Zhongmin TianThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Entai HouThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Ian R LanzaDivision of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Pengyuan LiuCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yong LiuCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Purushottam W LaudDivision of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
Kristie UsaCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yongcheng HeDepartment of Nephrology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Clinical Institute of Anhui Medical University, Shenzhen, Guangdong, P.R. China.
Mingyu LiangCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · USXi'an Jiaotong University · CNAnhui Medical University · CNMayo Clinic in Arizona · USShanghai Medical College of Fudan University · CN

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
TECHNOLOGY NMR SPECTROSCOPYU24DK100469 · NIDDK · MAYO CLINIC ROCHESTER · PI NAIR, K SREEKUMARAN · 2013 to 2017
$9.0M
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS P01 HL116264NIDDK NIH HHS U24 DK100469
6 · The paper itself

Abstract

Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically.

Indexed as

AdultAmino AcidsAminoisobutyric AcidsAnimalsBiogenic AminesBlood PressureCross-Over StudiesDietFemaleHumansHypertensionMaleMetabolomeMiddle AgedRatsRats, Inbred Dahl3-aminoisobutyric acidAmino AcidsAminoisobutyric AcidsBiogenic AminesSodium Chloride, Dietarydiethypertensionmetabolomicssalt

Identifiers

PMID29556335
PMCPMC5858161
OpenAlexW2789762868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.