Evidence map›Paper›PMID 29556316›Full record

ArticleOncology letters2018

Tumor suppressor microRNA-136-5p regulates the cellular function of renal cell carcinoma.

Peijie Chen, Liwen Zhao, Xiang Pan, Lu Jin, Canbin Lin, Weijie Xu, Jinling Xu, Xin Guan, Xueling Wu, Yong Wang and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  14. The Role of ERα36 in Development and Tumor Malignancy.International journal of molecular sciences · 2020
    Review
  15. Article
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  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Peijie ChenDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Liwen ZhaoDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Xiang PanDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Lu JinDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Canbin LinDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Weijie XuDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Jinling XuDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Xin GuanDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Xueling WuDepartment of Urology, Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, P.R. China.
Yong WangDepartment of Reproduction, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Shangqi YangDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Tao WangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Yongqing LaiDepartment of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.
Peking University Shenzhen Hospital · CNLonggang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRs) are involved in diverse physiological and developmental processes at the post-transcriptional level in cells. Previous studies have demonstrated that miR-136-5p is involved in certain types of cancer. However, the function of miR-136-5p in renal cell carcinoma (RCC) remains to be fully elucidated. In present study, miR-136-5p expression levels were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and MTT assays, CCK-8 assays, Transwell assays, wound healing assays and flow cytometry were performed to investigate the function of miR-136-5p in RCC. RT-qPCR revealed that the expression of miR-136 was significantly lower in RCC tissues and cells compared with adjacent non-tumor tissues and cells

Indexed as

microRNA-136-5prenal cell carcinomasuppressor

Identifiers

PMID29556316
PMCPMC5844007
OpenAlexW2791490799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.