Evidence map›Paper›PMID 29556230›Full record

ReviewFrontiers in immunology2018

Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice.

Kimberly Schmitt, Ramesh Akkina

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. HIV Reservoir: How to Measure It?Current HIV/AIDS reports · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Potential Pitfalls of the Humanized Mice in Modeling Sepsis.International journal of inflammation · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kimberly SchmittDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.
Ramesh AkkinaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Funding

An Ultrasensitive In Vivo Latent HIV Viral Outgrowth Assay Using Humanized MiceR01AI120021 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2015 to 2019
$3.4M
Modeling Next Generation HIV PrEP in Humanized MiceR01AI100845 · NIAID · COLORADO STATE UNIVERSITY · PI AKKINA, RAMESH · 2012 to 2014
$2.0M
NIAID NIH HHS R01 AI100845NIAID NIH HHS R01 AI120021
6 · The paper itself

Abstract

In the current quest for a complete cure for HIV/AIDS, highly sensitive HIV-1 latency detection methods are critical to verify full viral eradication. Until now, the

Indexed as

CD4-Positive T-LymphocytesAcquired Immunodeficiency SyndromeAnimalsBiological AssayHeterograftsHIV-1HumansMiceVirus ActivationVirus Latencycomparison of mVOA with humanized mouse-based viral outgrowth assaycomparison of quantitative viral outgrowth assays with humanized mouse-based viral outgrowth assayHIV-1 latent viral outgrowth assay using humanized micehumanized mouse-based HIV-1 latency outgrowth assaymouse-based HIV-1 viral outgrowth assaysnon-human primate-based latent simian immunodeficiency viral outgrowth assaysensitivity of humanized mouse-based viral outgrowth assay over mVOAultra-sensitive HIV-1 latent viral outgrowth assay in hu-mice

Identifiers

PMID29556230
PMCPMC5844934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.