Trial reportFrontiers in immunology2018
PIRCHE-II Is Related to Graft Failure after Kidney Transplantation.
Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 92 citations in OpenAlex.
- Donor/Recipient HLA Molecular Mismatch Scores Predict Primary Humoral and Cellular Alloimmunity in Kidney Transplantation.Frontiers in immunology · 2020Trial
- Predictive Value of HLA-Derived T-Cell Epitope and B-Cell Epitope Matching Algorithms for Pancreas Transplant Outcomes.Clinical transplantation · 2026Article
- Simulation of prospective PIRCHE-II molecular matching in Canada: a feasibility study.Frontiers in immunology · 2026Article
- Donor-recipient HLA molecular mismatch and T follicular helper-related genetic variants are associated with dnDSA development after kidney transplantation.Frontiers in immunology · 2026Article
- Evaluation of dnDSA risk stratification using the updated PIRCHE-T2 model in two kidney transplant cohorts.Frontiers in immunology · 2026Article
- Predicted Indirectly Recognizable T-cell Epitope (PIRCHE) Load Correlates With Rejection Events After Simultaneous Pancreas-Kidney Transplantation.Transplantation direct · 2025Article
- The Progress and Challenges of Implementing HLA Molecular Matching in Clinical Practice.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Early Donor-Specific HLA Antibodies Detected by Screening in the First Month Posttransplant and Kidney Graft Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compatibility.Frontiers in immunology · 2025Article
- Article
- Understanding HLA-DQ in renal transplantation: a mini-review.Frontiers in immunology · 2025Review
- Kidney Transplant Outcomes With Non-Depleting Antibody Induction Therapy in Human Leucocyte Antigen Sensitised Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing.Clinical transplantation and research · 2024Review
- Article
- Allogeneic HLA Humoral Immunogenicity and the Prediction of Donor-Specific HLA Antibody Development.Antibodies (Basel, Switzerland) · 2024Review
- The Clinical Significance of HLA Compatibility Scores in Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Observational
- Implications of MHC-restricted immunopeptidome in transplantation.Frontiers in immunology · 2024Review
- Donor-Specific Antibodies Targeting a Repeated Eplet Mismatch and Outcome After Kidney Retransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Improving long-term kidney allograft survival by rethinking HLA compatibility: from molecular matching to non-HLA genes.Frontiers in genetics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 13 institutions in 1 country.
Kirsten GeneugelijkLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Matthias NiemannPIRCHE AG, Berlin, Germany.
Julia DrylewiczLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Arjan D van ZuilenDepartment of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Irma JoostenLaboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.
Wil A AllebesLaboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.
Arnold van der MeerLaboratory Medicine, Laboratory Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.
Luuk B HilbrandsDepartment of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands.
Marije C BaasDepartment of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands.
C Erik HackLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Franka E van ReekumDepartment of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Marianne C VerhaarDepartment of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Elena G KamburovaLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Marc A J SeelenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jan Stephan SandersDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Bouke G HepkemaDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Annechien J LambeckDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Laura B BungenerDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Caroline RoozendaalDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Marcel G J TilanusDepartment of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands.
Joris VanderlochtCentral Diagnostic Laboratory, Division of Immunology, Maastricht University Medical Center, Maastricht, Netherlands.
Christien E VoorterDepartment of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands.
Lotte WietenDepartment of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, Netherlands.
Elly M van DuijnhovenDepartment of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands.
Mariëlle GelensDepartment of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands.
Maarten H L ChristiaansDepartment of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, Netherlands.
Frans J van IttersumDepartment of Nephrology, VU University Medical Center, Amsterdam, Netherlands.
Azam NurmohamedDepartment of Nephrology, VU University Medical Center, Amsterdam, Netherlands.
Junior N M LardyDepartment of Immunogenetics, Sanquin, Amsterdam, Netherlands.
Wendy SwelsenDepartment of Immunogenetics, Sanquin, Amsterdam, Netherlands.
Karlijn A van der PantRenal Transplant Unit, Department of Internal Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands.
Neelke C van der WeerdRenal Transplant Unit, Department of Internal Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands.
Ineke J M Ten BergeRenal Transplant Unit, Department of Internal Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands.
Fréderike J BemelmanRenal Transplant Unit, Department of Internal Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands.
Andries HoitsmaDutch Organ Transplant Registry (NOTR), Dutch Transplant Foundation (NTS), Leiden, Netherlands.
Paul J M van der BoogDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Johan W de FijterDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Michiel G H BetjesDepartment of Internal Medicine, Erasmus MC, Rotterdam, Netherlands.
Sebastiaan HeidtDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Dave L RoelenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Frans H ClaasDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Henny G OttenLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Eric SpieringsLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Maastricht University · NLUtrecht University · NLLeiden University Medical Center · NLAcademic Medical Center · NLUniversity Medical Center Groningen · NLRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NLAmsterdam UMC Location VUmc · NLRadboud University Medical Center · NLSanquin · NLUniversity of Groningen · NLDutch Heart Registry · NLErasmus University Rotterdam · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in
Indexed as
Histocompatibility TestingKidney TransplantationAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDonor SelectionFemaleGraft RejectionGraft SurvivalHLA AntigensHumansMaleMiddle AgedHLA Antigensgraft rejectionHLA antigensHLA matchingkidney transplantationPIRCHE-II
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.