ArticleFrontiers in neurology2018
Autonomic Nervous System and Stress to Predict Secondary Ischemic Events after Transient Ischemic Attack or Minor Stroke: Possible Implications of Heart Rate Variability.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Heart rate variability as a predictor of stroke course, functional outcome, and medical complications: A systematic review.Frontiers in physiology · 2023Pooled it
- A novel approach to the prevention and management of cardiovascular diseases: targeting brain-heart axis.European journal of medical research · 2025Review
- The global, regional, and National burden of severe heart failure (SHF) due to intracerebral hemorrhage, ischemic heart disease, or stroke, 1990-2021: a systematic analysis for the global burden of disease study 2021.BMC cardiovascular disorders · 2025Article
- Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Acute mental stress-induced alpha or beta-adrenergic reactivity patterns linked to unique cardiometabolic risk profiles.Scientific reports · 2025Article
- Stroke-heart syndrome: current progress and future outlook.Journal of neurology · 2024Review
- Stroke Related Brain-Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Language Preference and its Moderating Role in Coping with Stress: The Hispanic Community Health Study/Study of Latinos.Medical research archives · 2023Article
- Article
- Skin sympathetic nerve activity as a biomarker for outcomes in spontaneous intracerebral hemorrhage.Annals of clinical and translational neurology · 2023Article
- Effects of a Mobile-Health Exercise Intervention on Body Composition, Vascular Function, and Autonomic Nervous System Function in Obese Women: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2023Article
- Article
- Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine.Journal of applied biomedicine · 2022Article
- Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke.Frontiers in aging neuroscience · 2022Review
- Intracranial compliance in type 2 diabetes mellitus and its relationship with the cardiovascular autonomic nervous control.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Heart Rate Variability and Recurrent Stroke and Myocardial Infarction in Patients With Acute Mild to Moderate Stroke.Frontiers in neurology · 2021Article
- Heart Rate Variability in Schizophrenia and Autism.Frontiers in psychiatry · 2021Article
- Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation.Frontiers in cardiovascular medicine · 2021Article
- Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges.Nature communications · 2020Article
- Brain-heart interaction after acute ischemic stroke.Critical care (London, England) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient ischemic attack (TIA) and minor stroke have high risks of recurrence and deterioration into severe ischemic strokes. Risk stratification of TIA and minor stroke is essential for early effective treatment. Traditional tools have only moderate predictive value, likely due to their inclusion of the limited number of stroke risk factors. Our review follows Hans Selye's fundamental work on stress theory and the progressive shift of the autonomic nervous system (ANS) from adaptation to disease when stress becomes chronic. We will first show that traditional risk factors and acute triggers of ischemic stroke are chronic and acute stress factors or "stressors," respectively. Our first review shows solid evidence of the relationship between chronic stress and stroke occurrence. The stress response is tightly regulated by the ANS whose function can be assessed with heart rate variability (HRV). Our second review demonstrates that stress-related risk factors of ischemic stroke are correlated with ANS dysfunction and impaired HRV. Our conclusions support the idea that HRV parameters may represent the combined effects of all body stressors that are risk factors for ischemic stroke and, thus, may be of important predictive value for the risk of subsequent ischemic events after TIA or minor stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.