Evidence map›Paper›PMID 29556119›Full record

ArticleHealthcare informatics : the business magazine for information and communication systems2017

Deep Reinforcement Learning for Dynamic Treatment Regimes on Medical Registry Data.

Ying Liu, Brent Logan, Ning Liu, Zhiyuan Xu, Jian Tang, Yanzhi Wang

Abstract read
In one paragraph

Article in Healthcare informatics : the business magazine for information and communication systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Smart Imitator: Learning from Imperfect Clinical Decisions.Journal of the American Medical Informatics Association : JAMIA · 2026
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  18. Artificial Intelligence and the Implementation Challenge.Journal of medical Internet research · 2019
    Article
  19. Deep Reinforcement Learning in Medicine.Kidney diseases (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying LiuDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, 53226.
Brent LoganDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, 53226.
Ning LiuDepartment of Electrical Engineering and Computer Science, Syracuse University, Syracuse, NY, 13210.
Zhiyuan XuDepartment of Electrical Engineering and Computer Science, Syracuse University, Syracuse, NY, 13210.
Jian TangDepartment of Electrical Engineering and Computer Science, Syracuse University, Syracuse, NY, 13210.
Yanzhi WangDepartment of Electrical Engineering and Computer Science, Syracuse University, Syracuse, NY, 13210.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

In this paper, we propose the first deep reinforcement learning framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real life complexity in heterogeneous disease progression and treatment choices, with the goal to provide doctor and patients the data-driven personalized decision recommendations. The proposed deep reinforcement learning framework contains a supervised learning step to predict the most possible expert actions; and a deep reinforcement learning step to estimate the long term value function of Dynamic Treatment Regimes. We motivated and implemented the proposed framework on a data set from the Center for International Bone Marrow Transplant Research (CIBMTR) registry database, focusing on the sequence of prevention and treatments for acute and chronic graft versus host disease. We showed results of the initial implementation that demonstrates promising accuracy in predicting human expert decisions and initial implementation for the reinforcement learning step.

Indexed as

Machine LearningRegistriesHumansStatistics as Topic

Identifiers

PMID29556119
PMCPMC5856473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.