ReviewJournal of orthopaedics2018
Static antibiotic spacers augmented by calcium sulphate impregnated beads in revision TKA: Surgical technique and review of literature.
Review in Journal of orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The use of debridement, antibiotic pearls, and implant retention (DAPRI) in the management of acute periprosthetic joint infections: a systematic review.Journal of bone and joint infection · 2026Review
- Short-term follow-up of antibiotic-loaded calcium sulfate in treating chronic periprosthetic joint infection during two-stage revision.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Debridement, Antibiotic Pearls, and Retention of the Implant (DAPRI) in the Treatment of Early Periprosthetic Knee Joint Infections: A Literature Review.Healthcare (Basel, Switzerland) · 2024Review
- A Modified Technique for Two-Stage Revision in Knee PJI Treatment.Journal of clinical medicine · 2023Article
- Indications and techniques for non-articulating spacers in massive bone loss following prosthetic knee joint infection: a scoping review.Archives of orthopaedic and trauma surgery · 2023Article
- Spacer exchange in persistent periprosthetic joint infection: microbiological evaluation and survivorship analysis.Archives of orthopaedic and trauma surgery · 2023Article
- Are Static Spacers Superior to Articulated Spacers in the Staged Treatment of Infected Primary Knee Arthroplasty? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Do Antibiotic-Loaded Calcium Sulfate Beads Improve Outcomes After Debridement, Antibiotics, and Implant Retention? A Matched Cohort Study.Arthroplasty today · 2022Article
- Nanotechnology as an Anti-Infection Strategy in Periprosthetic Joint Infections (PJI).Tropical medicine and infectious disease · 2021Article
- The influence of a calcium sulphate bone void filler on the third-body damage and polyethylene wear of total knee arthroplasty.Bone & joint research · 2019Article
- Calcium sulphate mixed with antibiotics does not decrease efficacy againstJournal of orthopaedicsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periprosthetic joint infection (PJI) is a serious complication in total knee arthroplasty (TKA) and represents one of the most common causes of revision. The challenge for surgeons treating an infected TKA is to quickly obtain an infection-free joint in order to re-implant, when possible, a new TKA. Recent literature confirms the role of local antibiotic-loaded beads as a strong bactericidal, allowing higher antibiotic elution when compared with antibiotic loaded spacers only. Unfortunately, classical Polymethylmethacrylate (PMMA) beads might allow bacteria adhesion, secondary development of antibiotic resistance and eventually surgical removal once antibiotics have eluted. This article describes a novel surgical technique using static, custom-made antibiotic loaded spacers augmented by calcium sulphate antibiotic-impregnated beads to improve the success rate of revision TKA in a setting of PJI. The use of calcium sulphate beads has several potential benefits, including a longer sustained local antibiotic release when compared with classical PMMA beads and, being resorbable, not requiring accessory surgical interventions.
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