Evidence map›Paper›PMID 29556089›Full record

ArticleNature cell biology2018

EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans.

Piya Ghose, Alina Rashid, Peter Insley, Meera Trivedi, Pavak Shah, Anupriya Singhal, Yun Lu, Zhirong Bao, Shai Shaham

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. From wound response to repair - lessons from C. elegans.Cell regeneration (London, England) · 2021
    Review
  11. Fusogen-mediated neuron-neuron fusion disrupts neural circuit connectivity and alters animal behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Cell death in animal development.Development (Cambridge, England) · 2020
    Review
  13. How cells fuse.The Journal of cell biology · 2019
    Review
  14. Article
  15. The origins and evolution of macropinocytosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Piya GhoseLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Alina RashidLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Peter InsleyLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Meera TrivediLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Pavak ShahDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Anupriya SinghalLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Yun LuLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA.
Zhirong BaoDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Shai ShahamLaboratory of Developmental Genetics, The Rockefeller University, New York, NY, USA. shaham@rockefeller.edu.ORCID 0000-0002-3751-975X
Rockefeller University · USKettering University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Glial Control of Neuron Development and Function - Administrative SupplementR35NS105094 · NINDS · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2018 to 2025
$8.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
WormGUIDES: A Resource for Global Understanding in Dynamic Embryonic SystemsR24OD016474 · OD · YALE UNIVERSITY · PI BAO, ZHIRONG, COLON-RAMOS, DANIEL A · 2013 to 2020
$6.5M
The Ubiquitin-Proteasome System in Metazoan EmbryogenesisR01GM097576 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAO, ZHIRONG · 2011 to 2020
$3.3M
In Vivo Genetic Analysis of Compartmentalized Cell EliminationR35GM142489 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI GHOSE, PIYA · 2021 to 2025
$2.3M
Control of nonapoptotic C. elegans cell death similar to neurodegenerationR01NS081490 · NINDS · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2012 to 2017
$2.2M
Control of Linker Cell Death in C. elegansR01HD078703 · NICHD · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2014 to 2018
$1.7M
Novel Killing and Clearance Programs in a Morphologically Complex CellF32HD089640 · NICHD · ROCKEFELLER UNIVERSITY · PI GHOSE, PIYA · 2016 to 2018
$184k
NCI NIH HHS P30 CA008748NICHD NIH HHS F32 HD089640NICHD NIH HHS R01 HD078703NIGMS NIH HHS R01 GM097576NIGMS NIH HHS R35 GM142489NIH HHS P40 OD010440NIH HHS R24 OD016474NINDS NIH HHS R01 NS081490NINDS NIH HHS R35 NS105094
6 · The paper itself

Abstract

Phagocytosis of dying cells is critical in development and immunity

Indexed as

PhagocytosisAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DeathMembrane GlycoproteinsMutationNeuronsPhagocytesPhagosomesPseudopodiaSignal TransductionCaenorhabditis elegans ProteinsEFF-1 protein, C elegansMembrane Glycoproteins

Identifiers

PMID29556089
PMCPMC5876135
OpenAlexW2791942248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.