Evidence map›Paper›PMID 29556018›Full record

ArticleLeukemia2018

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses.

Tsewang Tashi, Sabina Swierczek, Soo Jin Kim, Mohamed E Salama, Jihyun Song, Nahla Heikal, Katherine Y King, Kim Hickman, Scott Litton, Josef T Prchal

Open access · greenAbstract read
In one paragraph

Article in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tsewang TashiDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Sabina SwierczekDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Soo Jin KimDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Mohamed E SalamaDepartment of Pathology, ARUP Institute of Research and Development, University of Utah School of Medicine, Salt Lake City, UT, USA.
Jihyun SongDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Nahla HeikalDepartment of Pathology, ARUP Institute of Research and Development, University of Utah School of Medicine, Salt Lake City, UT, USA.
Katherine Y KingDepartment of Pediatric Infectious Diseases and Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA.
Kim HickmanDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Scott LittonDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Josef T PrchalDivision of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA. josef.prchal@hsc.utah.edu.
University of Utah · USARUP Laboratories (United States) · USBaylor College of Medicine · US

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
MOLECULAR BIOLOGY OF PRIMARY POLYCYTHEMIAR01HL050077 · NHLBI · UNIVERSITY OF UTAH · PI PRCHAL, JOSEF T · 1993 to 2007
$2.0M
Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate ImmunityR01HL134880 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2017 to 2020
$1.6M
The Role of Interferon-gamma in the Regulation of Hematopoietic Stem CellsK08HL098898 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KING, KATHERINE YUDEH · 2010 to 2014
$653k
NHLBI NIH HHS K08 HL098898NHLBI NIH HHS R01 HL050077NHLBI NIH HHS R01 HL134880NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsAntiviral AgentsHumansHydroxyureaInterferon-alphaJanus Kinase 2MutationPolycythemia VeraPolyethylene GlycolsPrognosisRecombinant ProteinsThrombocythemia, EssentialTumor Cells, CulturedAntineoplastic AgentsAntiviral AgentsHydroxyureaInterferon-alphaJAK2 protein, humanJanus Kinase 2peginterferon alfa-2aPolyethylene GlycolsRecombinant Proteins

Identifiers

PMID29556018
PMCPMC6552660
OpenAlexW2793205496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.