Evidence map›Paper›PMID 29555854›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Ventromedial Prefrontal Cortex Is Necessary for Normal Associative Inference and Memory Integration.

Kelsey N Spalding, Margaret L Schlichting, Dagmar Zeithamova, Alison R Preston, Daniel Tranel, Melissa C Duff, David E Warren

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Neural Patterns Reflect Shared Emotional History.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  10. Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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  11. Review
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  17. Human ventromedial prefrontal cortex lesions enhance the effect of expectations on pain perception.Cortex; a journal devoted to the study of the nervous system and behavior · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kelsey N SpaldingDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa.
Margaret L SchlichtingDepartment of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada.ORCID 0000-0002-5433-8870
Dagmar ZeithamovaDepartment of Psychology, University of Oregon, Eugene, Oregon.
Alison R PrestonDepartments of Psychology and Neuroscience, The University of Texas at Austin, Austin, Texas.ORCID 0000-0003-2706-6862
Daniel TranelDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-1338-1389
Melissa C DuffDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, and.
David E WarrenDepartments of Neurological Sciences and Psychiatry, University of Nebraska Medical Center, Omaha, Nebraska 68198 david.warren@unmc.edu.ORCID 0000-0003-0539-2587

Funding

Hippocampal and prefrontal contributions to memory integrationR01MH100121 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Alison R Preston · 2013 to 2026
$7.3M
NIMH NIH HHS R01 MH100121
6 · The paper itself

Abstract

The ability to flexibly combine existing knowledge in response to novel circumstances is highly adaptive. However, the neural correlates of flexible associative inference are not well characterized. Laboratory tests of associative inference have measured memory for overlapping pairs of studied items (e.g., AB, BC) and for nonstudied pairs with common associates (i.e., AC). Findings from functional neuroimaging and neuropsychology suggest the ventromedial prefrontal cortex (vmPFC) may be necessary for associative inference. Here, we used a neuropsychological approach to test the necessity of vmPFC for successful memory-guided associative inference in humans using an overlapping pairs associative memory task. We predicted that individuals with focal vmPFC damage (

Indexed as

Association LearningMemoryAgedFemaleHumansMaleMemory DisordersMiddle AgedPrefrontal CortexVisual Perceptionassociative inferencelesionmemory integrationmemory systemsventromedial prefrontal cortexvmPFC

Identifiers

PMID29555854
PMCPMC5895999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.