Evidence map›Paper›PMID 29555775›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Identification and biosynthesis of thymidine hypermodifications in the genomic DNA of widespread bacterial viruses.

Yan-Jiun Lee, Nan Dai, Shannon E Walsh, Stephanie Müller, Morgan E Fraser, Kathryn M Kauffman, Chudi Guan, Ivan R Corrêa, Peter R Weigele

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  8. Uncovering ParB-dependent and -independent subclasses of T-dioxygenases from bacteriophage.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Rolling outMicrobial genomics · 2026
    Article
  11. Article
  12. Modified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxU.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  13. Treatment ofViruses · 2025
    Article
  14. Viruses · 2025
    Article
  15. Complete genome sequences ofmicroPublication biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Base-excision restriction enzymes: expanding the world of epigenetic immune systems.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan-Jiun LeeResearch Department, New England Biolabs, Ipswich, MA 01938.
Nan DaiResearch Department, New England Biolabs, Ipswich, MA 01938.
Shannon E WalshResearch Department, New England Biolabs, Ipswich, MA 01938.
Stephanie MüllerResearch Department, New England Biolabs, Ipswich, MA 01938.
Morgan E FraserResearch Department, New England Biolabs, Ipswich, MA 01938.
Kathryn M KauffmanDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Chudi GuanResearch Department, New England Biolabs, Ipswich, MA 01938.
Ivan R CorrêaResearch Department, New England Biolabs, Ipswich, MA 01938; correa@neb.com weigele@neb.com.ORCID 0000-0002-3169-6878
Peter R WeigeleResearch Department, New England Biolabs, Ipswich, MA 01938; correa@neb.com weigele@neb.com.
New England Biolabs (United States) · USMassachusetts Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Certain viruses of bacteria (bacteriophages) enzymatically hypermodify their DNA to protect their genetic material from host restriction endonuclease-mediated cleavage. Historically, it has been known that virion DNAs from the

Indexed as

BacteriaBacterial InfectionsBacterial ProteinsBacteriophagesDNA, ViralGenome, ViralThymidineUridineBacterial ProteinsDNA, ViralThymidineUridinebacteriophageDNA modificationhypermodificationpyrimidine

Identifiers

PMID29555775
PMCPMC5889632
OpenAlexW2793445989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.