ArticleProceedings of the National Academy of Sciences of the United States of America2018
Division-independent differentiation mandates proliferative competition among stem cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Article
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.bioRxiv : the preprint server for biology · 2025Article
- Mathematical modeling reveals cell differentiation processes and progenitor kinetics necessary for proper nephrogenesis.Frontiers in cell and developmental biology · 2025Article
- Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus.Stem cells (Dayton, Ohio) · 2024Article
- Article
- Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions.PLoS genetics · 2023Article
- Tough Gelatin Hydrogel for Tissue Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.BMC biology · 2023Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Investigating Adult Stem Cells Through Lineage analyses.Stem cell reviews and reports · 2022Review
- Adult stem cells and niche cells segregate gradually from common precursors that build the adulteLife · 2021Article
- Protocol for evaluating autophagy using LysoTracker staining in the epithelial follicle stem cells of theSTAR protocols · 2021Article
- A single-cell atlas and lineage analysis of the adult Drosophila ovary.Nature communications · 2020Article
- Article
- Signal transduction in the early Drosophila follicle stem cell lineage.Current opinion in insect science · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cancer-initiating gatekeeper mutations that arise in stem cells would be especially potent if they stabilize and expand an affected stem cell lineage. It is therefore important to understand how different stem cell organization strategies promote or prevent variant stem cell amplification in response to different types of mutation, including those that activate proliferation. Stem cell numbers can be maintained constant while producing differentiated products through individually asymmetrical division outcomes or by population asymmetry strategies in which individual stem cell lineages necessarily compete for niche space. We considered alternative mechanisms underlying population asymmetry and used quantitative modeling to predict starkly different consequences of altering proliferation rate: A variant, faster proliferating mutant stem cell should compete better only when stem cell division and differentiation are independent processes. For most types of stem cells, it has not been possible to ascertain experimentally whether division and differentiation are coupled. However,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.