Evidence map›Paper›PMID 29555731›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies.

Taylor C Stevenson, Colette Cywes-Bentley, Tyler D Moeller, Kevin B Weyant, David Putnam, Yung-Fu Chang, Bradley D Jones, Gerald B Pier, Matthew P DeLisa

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 99 citations in OpenAlex.

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  15. Outer Membrane Vesicle Vaccine Platforms.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Taylor C StevensonNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
Colette Cywes-BentleyDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Tyler D MoellerRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853.
Kevin B WeyantRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853.
David PutnamNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
Yung-Fu ChangDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-8902-3089
Bradley D JonesDepartment of Microbiology, University of Iowa, Iowa City, IA 52242.
Gerald B PierDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Matthew P DeLisaNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853; md255@cornell.edu.ORCID 0000-0003-3226-1566
Cornell University · USBrigham and Women's Hospital · USUniversity of Iowa · US

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2003 to 2013
$80.9M
Studies of the capsular-like antigen of F. tularensisP01AI044642 · NIAID · UNIVERSITY OF IOWA · PI NAUSEEF, WILLIAM M. · 1999 to 2014
$18.2M
Pathogensis of Bacterial corneal infectionR01EY016144 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI PIER, GERALD B · 2005 to 2018
$5.6M
Engineering Escherichia coli for glycosylation of complex human proteinsR44GM088905 · NIGMS · GLYCOBIA, INC. · PI FISHER, ADAM CHARLES · 2011 to 2012
$1.6M
Engineered Outer Membrane Vesicles as DNA Vaccine Delivery VehiclesR21EB005669 · NIBIB · CORNELL UNIVERSITY · PI PUTNAM, DAVID A · 2006 to 2007
$398k
Humanizing N-linked glycosylation in Escherichia coliR43GM088905 · NIGMS · GLYCOBIA, INC. · PI FISHER, ADAM CHARLES · 2009 to 2009
$116k
NEI NIH HHS R01 EY016144NIAID NIH HHS P01 AI044642NIAID NIH HHS U54 AI057160NIBIB NIH HHS R21 EB005669NIGMS NIH HHS R43 GM088905NIGMS NIH HHS R44 GM088905
6 · The paper itself

Abstract

Many microbial pathogens produce a β-(1→6)-linked poly-

Indexed as

AnimalsAntibodies, BacterialAntigens, SurfaceBacteriaBacterial InfectionsBacterial Vaccinesbeta-GlucansFemaleImmunizationMiceMice, Inbred BALB CTransport VesiclesVaccines, ConjugateAntibodies, BacterialAntigens, SurfaceBacterial Vaccinesbeta-Glucanspoly-N-acetyl-1-6-glucosamineVaccines, Conjugateglycoconjugate vaccineimmunizationinfectious diseaseoligosaccharidesynthetic biology

Identifiers

PMID29555731
PMCPMC5889644
OpenAlexW2793510065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.