Evidence map›Paper›PMID 29555670›Full record

ArticleCirculation. Genomic and precision medicine2018

Prospective Study of Epigenetic Age Acceleration and Incidence of Cardiovascular Disease Outcomes in the ARIC Study (Atherosclerosis Risk in Communities).

Nicholas S Roetker, James S Pankow, Jan Bressler, Alanna C Morrison, Eric Boerwinkle

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  9. Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas S RoetkerFrom the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (N.S.R., J.S.P.); Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (J.B., A.C.M., E.B.); and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.). roetk001@umn.edu.
James S PankowFrom the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (N.S.R., J.S.P.); Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (J.B., A.C.M., E.B.); and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.).
Jan BresslerFrom the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (N.S.R., J.S.P.); Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (J.B., A.C.M., E.B.); and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.).
Alanna C MorrisonFrom the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (N.S.R., J.S.P.); Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (J.B., A.C.M., E.B.); and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.).
Eric BoerwinkleFrom the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (N.S.R., J.S.P.); Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (J.B., A.C.M., E.B.); and Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.).
University of Minnesota · US

Funding

Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
NHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS RC2 HL102419
6 · The paper itself

Abstract

backgroundDNA methylation-based patterns of biological aging, known as epigenetic age acceleration, are predictive of all-cause mortality, but little is known about their association with cardiovascular disease (CVD).

methodsWe estimated 2 versions of epigenetic age acceleration (Horvath and Hannum) using whole-blood samples from 2543 blacks. Linear and Cox proportional hazards regression, respectively, were used to assess the association of age acceleration with carotid intima-media thickness (cross-sectionally) and incident cardiovascular events, including CVD mortality, myocardial infarction, fatal coronary heart disease, peripheral arterial disease, and heart failure, during a median 21-year follow-up. All models were adjusted for chronological age and traditional CVD risk factors.

resultsIn comparison to chronological age, the 2 measures of epigenetic age acceleration were weaker, but independent, potential risk markers for subclinical atherosclerosis and most incident cardiovascular outcomes, including fatal coronary heart disease, peripheral arterial disease, and heart failure. For example, each 5-year increment of epigenetic age acceleration was associated with an average of 0.01 mm greater carotid intima-media thickness (each

conclusionsIn this sample of blacks, increased epigenetic age acceleration in whole blood was a potential risk marker for incident fatal coronary heart disease, peripheral arterial disease, and heart failure independently of chronological age and traditional CVD risk factors. DNA methylation-based measures of biological aging may help to identify new pathophysiological mechanisms contributing to the development of CVD.

Indexed as

Age FactorsBlack or African AmericanCardiovascular DiseasesCarotid Intima-Media ThicknessDNA MethylationFemaleHumansMaleMiddle AgedPrevalenceProportional Hazards ModelsProspective StudiesRisk Factorsagingcardiovascular diseaseepidemiologyepigenomicsrisk factors

Identifiers

PMID29555670
PMCPMC5863591
OpenAlexW2790137094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.