Evidence map›Paper›PMID 29555629›Full record

ArticleAntimicrobial agents and chemotherapy2018

TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates.

Alexandre Luscher, Lucile Moynié, Pamela Saint Auguste, Dirk Bumann, Lena Mazza, Daniel Pletzer, James H Naismith, Thilo Köhler

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 121 citations in OpenAlex.

  1. Trial
  2. ISEmerging microbes & infections · 2026
    Article
  3. Observational
  4. Identification of iron and zinc responsive TonB-dependent transporters in Pseudomonas aeruginosa.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  5. Cefiderocol nonsusceptibility among carbapenem-resistantAntimicrobial agents and chemotherapy · 2026
    Article
  6. Mechanisms involved in cefiderocol resistance in FrenchAntimicrobial agents and chemotherapy · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Broadly Defined Antibiotic Adjuvants forThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  14. Review
  15. Activity of cefiderocol againstMicrobiology spectrum · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Alexandre LuscherService of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland.
Lucile MoyniéSchool of Chemistry and Biomedical Sciences Research Complex, University of St Andrews, Fife, Scotland, United Kingdom.
Pamela Saint AugusteBiozentrum, University of Basel, Basel, Switzerland.
Dirk BumannBiozentrum, University of Basel, Basel, Switzerland.
Lena MazzaService of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland.
Daniel PletzerJacobs University, Bremen, Germany.ORCID 0000-0001-5750-7505
James H NaismithSchool of Chemistry and Biomedical Sciences Research Complex, University of St Andrews, Fife, Scotland, United Kingdom.
Thilo KöhlerService of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland thilo.kohler@unige.ch.
University of Geneva · CHUniversity of Basel · CHUniversity of St Andrews · GBConstructor University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dependent receptors (TBDR), which are involved in the uptake of essential nutrients, including iron. Previous reports have demonstrated the involvement of the TBDRs PiuA and PirA from

Indexed as

Anti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial Proteinsbeta-LactamsBiological TransportCarrier ProteinsCefiderocolCell Membrane PermeabilityCephalosporinsMembrane ProteinsMonobactamsPseudomonas aeruginosaSiderophoresThiazolesAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsBAL 30072beta-LactamsCarrier ProteinsCefiderocolCephalosporinsMC-1 beta-lactam compoundMembrane ProteinsMonobactamsSiderophoresThiazolestonB protein, BacteriaPseudomonas aeruginosasiderophore-drug conjugateTonB-dependent receptor

Identifiers

PMID29555629
PMCPMC5971595
OpenAlexW2804005806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.