Evidence map›Paper›PMID 29555627›Full record

ArticleAntimicrobial agents and chemotherapy2018

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.

Suzanne Scheele, Jennifer A Geiger, Amy E DeRocher, Ryan Choi, Tess R Smith, Matthew A Hulverson, Rama Subba Rao Vidadala, Lynn K Barrett, Dustin J Maly, Ethan A Merritt and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Exploring the Inhibition ofInternational journal of molecular sciences · 2024
    Article
  2. Cloning, expression, and purification of an α-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Protein kinases in Toxoplasma gondii.International journal for parasitology · 2021
    Review
  7. Article
  8. Hydroxylamine and Carboxymethoxylamine Can InhibitAntimicrobial agents and chemotherapy · 2020
    Article
  9. Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro.International journal for parasitology. Drugs and drug resistance · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Suzanne Scheele *Center for Infectious Disease Research, Seattle, Washington, USA.
Jennifer A Geiger *Center for Infectious Disease Research, Seattle, Washington, USA.
Amy E DeRocher *Center for Infectious Disease Research, Seattle, Washington, USA.
Ryan ChoiDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Tess R SmithDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Matthew A HulversonDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Rama Subba Rao VidadalaDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
Lynn K BarrettDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Dustin J MalyDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
Ethan A MerrittDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Kayode K OjoDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Wesley C Van VoorhisDepartment of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.
Marilyn ParsonsCenter for Infectious Disease Research, Seattle, Washington, USA marilyn.parsons@cidresearch.org.ORCID 0000-0003-3994-8096
University of Washington · USCenter for Infectious Disease Research · US

Funding

Bumped Kinase Inhibitors: Novel Therapeutics for Cryptosporidiosis&ToxoplasmosisR01AI111341 · NIAID · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2014 to 2018
$6.4M
Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvumR01AI089441 · NIAID · UNIVERSITY OF WASHINGTON · PI MERRITT, ETHAN A, PARSONS, MARILYN · 2010 to 2014
$5.0M
Dual Use Therapeutics for Cryptosporidiosis, Toxoplasmosis, and NeosporosisR01HD080670 · NICHD · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI089441NIAID NIH HHS R01 AI111341NICHD NIH HHS R01 HD080670
6 · The paper itself

Abstract

In

Indexed as

AnimalsDrug ResistanceFocal Adhesion Kinase 2HumansNaphthalenesPiperidinesProtein Kinase InhibitorsProtozoan ProteinsPyrazolesToxoplasmaToxoplasmosisbumped kinase inhibitor 1294Focal Adhesion Kinase 2NaphthalenesPiperidinesProtein Kinase InhibitorsProtozoan ProteinsPyrazolesbumped kinase inhibitorcellular thermal shift assayinhibitorprotein kinaseToxoplasma gondii

Identifiers

PMID29555627
PMCPMC5971589
OpenAlexW2789743887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.