Evidence map›Paper›PMID 29555181›Full record

ReviewTrends in neurosciences2018

Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging.

Sara N Burke, Leslie S Gaynor, Carol A Barnes, Russell M Bauer, Jennifer L Bizon, Erik D Roberson, Lee Ryan

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  19. 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara N BurkeMcKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA; Institute on Aging, University of Florida, Gainesville, FL, USA. Electronic address: burkes@ufl.edu.
Leslie S GaynorMcKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Carol A BarnesEvelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA; Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, USA; Department of Psychology, University of Arizona, Tucson, AZ, USA; Department of Neurology and Neuroscience, University of Arizona, Tucson, AZ, USA.
Russell M BauerDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Jennifer L BizonMcKnight Brain Institute, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Erik D RobersonEvelyn F. McKnight Brain Institute, Alzheimer's Disease Center, Center for Neurodegeneration and Experimental Therapeutics, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, AL, USA.
Lee RyanEvelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA; Department of Psychology, University of Arizona, Tucson, AZ, USA. Electronic address: ryant@email.arizona.edu.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NEUROBEHAVIORAL RELATIONS IN SENESCENT HIPPOCAMPUSR01AG003376 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI BARNES, CAROL A. · 1985 to 2025
$16.4M
The contribution of declines in functional connectivity to cognitive agingR01AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2016 to 2025
$3.2M
Neural Mechanisms of Cognitive Decline in AgingR01AG029421 · NIA · UNIVERSITY OF FLORIDA · PI BIZON, JENNIFER LYNN · 2007 to 2018
$3.1M
The contribution of declines in functional connectivity to cognitive agingRF1AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2021 to 2021
$2.0M
Mechanisms for the Benefit of Tau Reduction in Alzheimer Disease ModelsR01NS075487 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROBERSON, ERIK D · 2011 to 2015
$1.6M
NCATS NIH HHS UL1 TR001427NIA NIH HHS R01 AG003376NIA NIH HHS R01 AG029421NIA NIH HHS R01 AG049722NIA NIH HHS RF1 AG049722NINDS NIH HHS R01 NS075487
6 · The paper itself

Abstract

A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. However, known anatomical connectivity, together with recent electrophysiological, neuroimaging, and lesion data, indicate that both brain areas participate in spatial and nonspatial processing. Instead of content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical-hippocampal networks: one network that is tuned to process coarse information quickly, forming gist-like representations of scenes/environments, and a second network tuned to process information about the specific sensory details that are necessary for discrimination across sensory modalities. The available data suggest that the latter network may be more vulnerable in advanced age.

Indexed as

Cognitive AgingAge FactorsAnimalsCognitionHumansNeural PathwaysParahippocampal GyrusPerirhinal Cortexentorhinal cortexhippocampusmemoryMRIpostrhinal cortexprocess model

Identifiers

PMID29555181
PMCPMC5970964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.