ArticleBehavioral and brain functions : BBF2018
Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.
Article in Behavioral and brain functions : BBF, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026Review
- The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review.Cureus · 2025Review
- Social fear extinction susceptibility is associated with Microbiota-Gut-Brain axis alterations.Brain, behavior, and immunity · 2024Article
- Article
- Subgenual and Hippocampal Pathways in Amygdala Are Set to Balance Affect and Context Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice.Molecular neurobiology · 2021Article
- Review
- Prefrontal GABAergic Interneurons Gate Long-Range Afferents to Regulate Prefrontal Cortex-Associated Complex Behaviors.Frontiers in neural circuits · 2021Review
- Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats.Brain, behavior, and immunity · 2021Article
- Neural circuits for coping with social defeat.Current opinion in neurobiology · 2020Review
- The zebrafish subcortical social brain as a model for studying social behavior disorders.Disease models & mechanisms · 2019Review
- Functional Neurochemistry of the Ventral and Dorsal Hippocampus: Stress, Depression, Dementia and Remote Hippocampal Damage.Neurochemical research · 2019Article
- Importance of Temporal Analyzes for the Exploration of the Posturographic Correlates of Emotional Processing.Frontiers in behavioral neuroscience · 2018Review
- Neurobiological Aspects of Face Recognition: The Role of Oxytocin.Frontiers in behavioral neuroscience · 2018Review
- Vasotocin influences mother-offspring associations in a facultatively family-living lizard.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundFollowing a social defeat, the balanced establishment and extinction of aversive information is a beneficial strategy for individual survival. Abnormal establishment or extinction is implicated in the development of mental disorders. This study investigated the time course of the establishment and extinction of aversive information from acute social defeat and the temporal responsiveness of the basolateral amygdala (BLA), ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) in this process.
methodsMouse models of acute social defeat were established by using the resident-intruder paradigm. To evaluate the engram of social defeat, the intruder mice were placed into the novel context at designated time to test the social behavior. Furthermore, responses of BLA, vHIP and mPFC were investigated by analyzing the expression of immediate early genes, such as zif268, arc, and c-fos.
resultsThe results showed after an aggressive attack, aversive memory was maintained for approximately 7 days before gradually diminishing. The establishment and maintenance of aversive stimulation were consistently accompanied by BLA activity. By contrast, vHIP and mPFC response was inhibited from this process. Additionally, injecting muscimol (Mus), a GABA receptor agonist, into the BLA alleviated the freezing behavior and social fear and avoidance. Simultaneously, Mus treatment decreased the zif268 and arc expression in BLA, but it increased their expression in vHIP.
conclusionOur data support and extend earlier findings that implicate BLA, vHIP and mPFC in social defeat. The time courses of the establishment and extinction of social defeat are particularly consistent with the contrasting BLA and vHIP responses involved in this process.
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