ArticleParasites & vectors2018
Does co-infection with vector-borne pathogens play a role in clinical canine leishmaniosis?
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis.Veterinary dermatology · 2025Guideline
- Co-infections of rickettsiales in clinically healthy, Leishmania infantum seropositive and seronegative dogs: a systematic literature review and new findings from Southern Italy.Parasitology research · 2025Pooled it
- Updated Canine Leishmaniosis Working Group recommendations for leishmaniosis in dogs: Q&A on clinical management.Parasites & vectors · 2026Review
- Three Leishmania species identified in domestic dogs in Tunisia: New insights into canine leishmaniosis.PLoS neglected tropical diseases · 2026Article
- Breed-specific immune regulation under endemic exposure to Leishmania infantum and other vector-borne pathogens in a native Mediterranean canine population.Parasites & vectors · 2026Article
- Epidemiological surveillance of canine visceral leishmaniasis in a municipality in the Western Amazon.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Tick-borne coinfections modulate CD8Infection and immunity · 2025Article
- Impact of single versus multiple infection on serum protein fractions in cats.Veterinary research communications · 2025Article
- Article
- First detection of Leishmania major in dogs living in an endemic area of zoonotic cutaneous leishmaniasis in Tunisia.Parasites & vectors · 2024Article
- Article
- Microfluidic PCR and network analysis reveals complex tick-borne pathogen interactions in the tropics.Parasites & vectors · 2024Article
- Within-host bayesian joint modeling of longitudinal and time-to-event data of Leishmania infection.PloS one · 2024Article
- Ehrlichia spp. infection worsens cardiac damage in dogs with canine visceral leishmaniasis.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2024Article
- Molecular survey on vector-borne pathogens in clinically healthy stray cats in Zaragoza (Spain).Parasites & vectors · 2023Article
- A blinded, randomized and controlled multicenter clinical trial to assess the efficacy and safety of LeisguardParasites & vectors · 2023Article
- Bayesian multivariate longitudinal model for immune responses to Leishmania: A tick-borne co-infection study.Statistics in medicine · 2023Article
- Modulation of Macrophage Redox and Apoptotic Processes toPathogens (Basel, Switzerland) · 2023Article
- Clinical, diagnostic and epidemiological implications of Hepatozoon spp., Babesia spp. and Leishmania infantum infection in cats and dogs in a Mediterranean periurban setting.Parasitology research · 2023Article
- Seropositivity of main vector-borne pathogens in dogs across Europe.Parasites & vectors · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe severity of canine leishmaniosis (CanL) due to Leishmania infantum might be affected by other vector-borne organisms that mimic its clinical signs and clinicopathological abnormalities. The aim of this study was to determine co-infections with other vector-borne pathogens based on serological and molecular techniques in dogs with clinical leishmaniosis living in Spain and to associate them with clinical signs and clinicopathological abnormalities as well as disease severity.
methodsSixty-one dogs with clinical leishmaniosis and 16 apparently healthy dogs were tested for Rickettsia conorii, Ehrlichia canis, Anaplasma phagocytophilum and Bartonella henselae antigens by the immunofluorescence antibody test (IFAT) and for E. canis, Anaplasma spp., Hepatozoon spp., Babesia spp. and filarioid DNA by polymerase chain reaction (PCR).
resultsAmong the dogs examined by IFAT, the seroprevalences were: 69% for R. conorii, 57% for E. canis, 44% for A. phagocytophilum and 37% for B. henselae; while the prevalences found by PCR were: 8% for Ehrlichia/Anaplasma, 3% for Anaplasma platys and 1% for H. canis. No other pathogen DNA was detected. Statistical association was found between dogs with clinical leishmaniosis and seroreactivity to R. conorii antigen (Fisher's exact test: P = 0.025, OR = 4.1, 95% CI = 1-17) and A. phagocytophilum antigen (Fisher's exact test: P = 0.002, OR = 14.3, 95% CI = 2-626) and being positive to more than one serological or molecular tests (co-infections) (Mann-Whitney test: U = 243, Z = -2.6, n
conclusionsThis study demonstrates that dogs with clinical leishmaniosis from Catalonia (Spain) have a higher rate of co-infections with other vector-borne pathogens when compared with healthy controls. Furthermore, positivity to some vector-borne pathogens was associated with more marked clinicopathological abnormalities as well as disease severity with CanL.
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