Evidence map›Paper›PMID 29554910›Full record

ArticleJournal of nanobiotechnology2018

Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release.

Zhongjun Cheng, Xiaoliang Chen, Dongliang Zhai, Feiyan Gao, Tingwang Guo, Wenfeng Li, Shilei Hao, Jingou Ji, Bochu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 76 citations in OpenAlex.

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  18. Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications.International journal of molecular sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zhongjun ChengKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China.
Xiaoliang ChenDepartment of Nuclear Medicine, Chongqing Cancer Institution, Chongqing, 400030, China.
Dongliang ZhaiDepartment of Nuclear Medicine, Chongqing Cancer Institution, Chongqing, 400030, China.
Feiyan GaoKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China.
Tingwang GuoKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China.
Wenfeng LiKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China.
Shilei HaoKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China. shilei_hao@cqu.edu.cn.ORCID http://orcid.org/0000-0003-1205-3102
Jingou JiCollege of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, China. 725_tiger@sina.com.
Bochu WangKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China. wangbc2000@126.com.
Chongqing University · CNChongqing Cancer Hospital · CN

Funding

Fundamental Research Funds for the Central Universities 106112017CDJXY230006Fundamental Research Funds for the Central Universities 10611CDJXZ238826National Basic Research Program of China 2014CB541603National Natural Science Foundation of China 31600770
6 · The paper itself

Abstract

backgroundNanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery. However, few reports have focused on the keratin-based mucoadhesive drug delivery system and their mechanisms of mucoadhesion. Thus, the mucoadhesion controlled kerateine (reduced keratin, KTN)/keratose (oxidized keratin, KOS) composite nanoparticles were prepared via adjusting the proportion of KTN and KOS to achieve controlled gastric mucoadhesion and drug release based on their different mucoadhesive abilities and pH-sensitive properties. Furthermore, the mechanisms of mucoadhesion for KTN and KOS were also investigated in the present study.

resultsThe composite keratin nanoparticles (KNPs) with different mass ratio of KTN to KOS, including 100/0 (KNP-1), 75/25 (KNP-2), 50/50 (KNP-3), and 25/75 (KNP-4), displayed different drug release rates and gastric mucoadhesion capacities, and then altered the drug pharmacokinetic performances. The stronger mucoadhesive ability of nanoparticle could supply longer gastric retention time, indicating that KTN displayed a stronger mucoadhesion than that of KOS. Furthermore, the mechanisms of mucoadhesion for KTN and KOS at different pH conditions were also investigated. The binding between KTN and porcine gastric mucin (PGM) is dominated by electrostatic attractions and hydrogen bondings at pH 4.5, and disulfide bonds also plays a key role in the interaction at pH 7.4. While, the main mechanisms of KOS and PGM interactions are hydrogen bondings and hydrophobic interactions in pH 7.4 condition and were hydrogen bondings at pH 4.5.

conclusionsThe resulting knowledge offer an efficient strategy to control the gastric mucoadhesion and drug release of nano drug delivery systems, and the elaboration of mucoadhesive mechanism of keratins will enable the rational design of nanocarriers for specific mucoadhesive drug delivery.

Indexed as

Delayed-Action PreparationsAmoxicillinAnimalsDrug CompoundingDrug LiberationGastric MucosaGastrointestinal AbsorptionHydrogen-Ion ConcentrationKeratinsMaleMucinsNanoparticlesOxidation-ReductionProtein BindingRatsRats, Sprague-DawleyAmoxicillinDelayed-Action PreparationsKeratinsMucinsBioavailabilityControlled drug releaseKerateineKeratoseMucoadhesion

Identifiers

PMID29554910
PMCPMC5858146
OpenAlexW2805810201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.