Evidence map›Paper›PMID 29554907›Full record

ArticleAnnals of clinical microbiology and antimicrobials2018

Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units.

Zhi-Hui Zou, Dong Liu, Hong-Dong Li, Dan-Ping Zhu, Yu He, Ting Hou, Jia-Lin Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 8 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 8 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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  17. Bowel habits in preterm infants: Observations from the first 2 weeks of life.Journal of pediatric gastroenterology and nutrition · 2025
    Observational
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhi-Hui ZouDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Dong LiuDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Hong-Dong LiDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Dan-Ping ZhuDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Yu HeDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Ting HouDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Jia-Lin YuDepartment of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. yujialin486@126.com.
Children's Hospital of Chongqing Medical University · CNMaternal and Child Health Hospital of Sichuan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore the influences of prenatal antibiotic exposure, the intensity of prenatal and postnatal antibiotic exposure on gut microbiota of preterm infants and whether gut microbiota and drug resistant strains in the neonatal intensive care unit (NICU) over a defined period are related.

methodsAmong 28 preterm infants, there were two groups, the PAT (prenatal antibiotic therapy) group (12 cases), and the PAF (prenatal antibiotic free) group (12 cases). Fecal samples from both groups were collected on days 7 and 14. According to the time of prenatal and postnatal antibiotic exposure, cases were divided into two groups, H (high) group (11 cases) and L (low) group (11 cases), and fecal samples on day 14 were collected. Genomic DNA was extracted from the fecal samples and was subjected to high throughput 16S rRNA amplicon sequencing. Bioinformatics methods were used to analyze the sequencing results.

resultsPrenatal and postnatal antibiotic exposure exercised influence on the early establishment of intestinal microflora of preterm infants. Bacteroidetes decreased significantly in the PAT group (p < 0.05). The number of Bifidobacterium significantly decreased in the PAT group and H group (p < 0.05). The early gut microbiota of preterm infants with prenatal and postnatal antibiotic exposure was similar to resistant bacteria in NICU during the same period.

conclusionPrenatal and postnatal antibiotic exposure may affect the composition of early gut microbiota in preterm infants. Antibiotic-resistant bacteria in NICU may play a role in reshaping the early gut microbiota of preterm infants with prenatal and postnatal antibiotic exposure.

Indexed as

Infant, PrematureAnti-Bacterial AgentsBacteriaDNA, BacterialDrug Resistance, BacterialFecesFemaleGastrointestinal MicrobiomeGestational AgeHigh-Throughput Nucleotide SequencingHumansInfant FoodInfant, NewbornIntensive Care Units, NeonatalIntestinesMaleAnti-Bacterial AgentsDNA, BacterialRNA, Ribosomal, 16SAnti-bacterial agentsGastrointestinal microbiomeHigh-throughput nucleotide sequencingInfant, prematureIntensive care unit, neonatal

Identifiers

PMID29554907
PMCPMC5858143
OpenAlexW2803865637

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.