Evidence map›Paper›PMID 29554902›Full record

ArticleBMC medicine2018

Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study.

Daniel J Gottlieb, Jeffrey M Ellenbogen, Matt T Bianchi, Charles A Czeisler

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517150 (Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517150 naunknown statusnot on this map

Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III

TypeinterventionalSponsorUniversity of Sao PauloRan2016 to 2018Enrolled60ConditionsObstructive Sleep Apnea, ObesityArmsmandibular advancement device
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Attention Regulation Among Sleep-Deprived Air-Force Pilots.Journal of neuroscience research · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Focusing on sleep health for all, not just sleep disorders.Canadian journal of public health = Revue canadienne de sante publique · 2025
    Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Daniel J GottliebDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, 221 Longwood Ave, BLI 225E, Boston, MA, 02115, USA. djgottlieb@partners.org.
Jeffrey M EllenbogenDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Matt T BianchiDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham & Women's Hospital, 221 Longwood Ave, BLI 225E, Boston, MA, 02115, USA.
Harvard University · USCircadian (United States) · USMassachusetts General Hospital · US

Funding

TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI QUAN, STUART F. · 1991 to 2018
$23.1M
Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCCU01HL111478 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, LANDRIGAN, CHRISTOPHER PAUL · 2012 to 2017
$8.4M
DATA COORDINATING CENTER FOR SLEEP HEART STUDYU01HL064360 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DIENER-WEST, MARIE · 1999 to 2007
$4.4M
THE SLEEP HEART HEALTH STUDY: READING CENTER APPLICATIONU01HL063463 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI REDLINE, SUSAN S. · 1999 to 2007
$2.8M
Multi-scale modeling of sleep behaviors in social networksR01GM105018 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, KLERMAN, ELIZABETH B. · 2013 to 2017
$2.4M
The Sleep Heart Health Study (SHHS)U01HL053938 · NHLBI · UNIVERSITY OF ARIZONA · PI QUAN, STUART F. · 1994 to 2007
$2.0M
SLEEP HEART HEALTH STUDYU01HL053931 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAPOPORT, DAVID M. · 1994 to 2003
$1.9M
Effects of Attending Surgeon and Obstetrician Fatigue on Operating Room SafetyR01HL095472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 2009 to 2012
$1.8M
THE SLEEP HEART HEALTH STUDYU01HL053937 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUNJABI, NARESH · 1994 to 2007
$1.6M
SLEEP HEART HEALTH STUDYU01HL063429 · NHLBI · MISSOURI BREAKS RESEARCH, INC. · PI RESNICK, HELAINE E. · 1999 to 2007
$1.5M
SLEEP HEART HEALTH STUDYU01HL053916 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1994 to 2007
$1.5M
THE SLEEP HEART HEALTH STUDYU01HL053934 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHAHAR, EYAL · 1994 to 2007
$1.4M
NHLBI NIH HHS HL095472NHLBI NIH HHS HL94654NHLBI NIH HHS R01 HL094654NHLBI NIH HHS R01 HL095472NHLBI NIH HHS U01 HL053916NHLBI NIH HHS U01 HL053931NHLBI NIH HHS U01 HL053934NHLBI NIH HHS U01 HL053937NHLBI NIH HHS U01 HL053938NHLBI NIH HHS U01 HL053941NHLBI NIH HHS U01 HL063429NHLBI NIH HHS U01 HL063463NHLBI NIH HHS U01 HL064360NHLBI NIH HHS U01 HL111478NHLBI NIH HHS U01HL111478NHLBI NIH HHS U01HL53941NIA NIH HHS P01 AG009975NIA NIH HHS P01AG009975NIGMS NIH HHS GM105018NIGMS NIH HHS R01 GM105018
6 · The paper itself

Abstract

backgroundInsufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their contribution to crash risk in the general population remains uncertain. The objective of this study was to evaluate the relation of sleep apnea, sleep duration, and excessive sleepiness to crash risk in a community-dwelling population.

methodsThis was a prospective observational cohort study nested within the Sleep Heart Health Study, a community-based study of the health consequences of sleep apnea. The participants were 1745 men and 1456 women aged 40-89 years. Sleep apnea was measured by home polysomnography and questionnaires were used to assess usual sleep duration and daytime sleepiness. A follow-up questionnaire 2 years after baseline ascertained driving habits and motor vehicle crash history. Logistic regression analysis was used to examine the relation of sleep apnea and sleep duration at baseline to the occurrence of motor vehicle crashes during the year preceding the follow-up visit, adjusting for relevant covariates. The population-attributable fraction of motor vehicle crashes was estimated from the sample proportion of motor vehicle crashes and the adjusted odds ratios for motor vehicle crash within each exposure category.

resultsAmong 3201 evaluable participants, 222 (6.9%) reported at least one motor vehicle crash during the prior year. A higher apnea-hypopnea index (p < 0.01), fewer hours of sleep (p = 0.04), and self-reported excessive sleepiness (p < 0.01) were each significantly associated with crash risk. Severe sleep apnea was associated with a 123% increased crash risk, compared to no sleep apnea. Sleeping 6 hours per night was associated with a 33% increased crash risk, compared to sleeping 7 or 8 hours per night. These associations were present even in those who did not report excessive sleepiness. The population-attributable fraction of motor vehicle crashes was 10% due to sleep apnea and 9% due to sleep duration less than 7 hours.

conclusionsSleep deficiency due to either sleep apnea or insufficient sleep duration is strongly associated with motor vehicle crashes in the general population, independent of self-reported excessive sleepiness.

Indexed as

Accidents, TrafficAdultCohort StudiesDisorders of Excessive SomnolenceFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSleep DeprivationEpidemiologyMotor vehicle accidentMotor vehicle crashSleep apneaSleep deficiencySleep deprivationSleep duration

Identifiers

PMID29554902
PMCPMC5859531
OpenAlexW2794823540

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.