ArticleBMC genomics2018
Comparative genomic and metabolic analysis of three Lactobacillus paracasei cheese isolates reveals considerable genomic differences in strains from the same niche.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hybrid genome assembly and phenotypic assays reveal carbohydrate metabolism diversity in Lacticaseibacillus strains.Applied microbiology and biotechnology · 2026Article
- Genetically Modified Lactic Acid Bacteria in the EU Food Chain: Applications, Benefits, and Risk Assessment.International journal of molecular sciences · 2026Review
- Bile Salt Tolerance Determines Intestinal Colonization Efficacy ofInternational journal of molecular sciences · 2026Article
- Article
- Long-read, multi-amplicon sequencing to explore genetic diversity associated with starch degrading phenotypes in amylolyticFrontiers in microbiology · 2025Article
- Comprehensive Safety Assessment ofCurrent issues in molecular biology · 2024Article
- Complete genome sequence ofMicrobiology resource announcements · 2024Article
- Probiotic Insights from the Genomic Exploration ofFoods (Basel, Switzerland) · 2024Article
- Draft Genome Sequence and Comparative Genome Analysis Reveal Potential Functional Properties in Lacticaseibacillus paracasei ItalPN16.Current microbiology · 2023Article
- Population genomics of Lacticaseibacillus paracasei: pan-genome, integrated prophage, antibiotic resistance, and carbohydrate utilization.World journal of microbiology & biotechnology · 2023Article
- Comparative genomic analysis ofFrontiers in microbiology · 2022Article
- Health-Promoting Properties ofFoods (Basel, Switzerland) · 2021Review
- Characterization of a bacterial strain Lactobacillus paracasei LP10266 recovered from an endocarditis patient in Shandong, China.BMC microbiology · 2021Article
- Genome Sequencing of fiveMicroorganisms · 2021Article
- Complete Genome Sequencing and Comparative Genomics of Three Potential Probiotic Strains,Frontiers in microbiology · 2021Article
- Niche-Specific Adaptive Evolution ofFrontiers in cellular and infection microbiology · 2020Article
- Comparative genomics and functional analysis of a highly adhesive dairy Lactobacillus paracasei subsp. paracasei IBB3423 strain.Applied microbiology and biotechnology · 2019Article
- Complete Genome Sequence of Lactobacillus paracasei EG9, a Strain Accelerating Free Amino Acid Production during Cheese Ripening.Genome announcements · 2018Article
- How the Fewest Become the Greatest.Frontiers in microbiology · 2018Review
- Genetic Signatures of DairyFrontiers in microbiology · 2018Article
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2 authors.
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Abstract
backgroundStrains of Lactobacillus paracasei are present in many diverse environments, including dairy and plant materials and the intestinal tracts of humans and animals. Their adaptation to various niches is correlated to intra-species diversity at the genomic and metabolic level. In this study, we compared the genome sequences of three L. paracasei strains isolated from mature Cheddar cheeses, two of which (DPC4206 and DPC4536) shared the same genomic fingerprint by PFGE, but demonstrated varying metabolic capabilities.
resultsGenome sizes varied from 2.9 Mbp for DPC2071, to 3.09 Mbp for DPC4206 and 3.08 Mpb for DPC4536. The presence of plasmids was a distinguishing feature between the strains with strain DPC2071 possessing an unusually high number of plasmids (up to 11), while DPC4206 had one plasmid and DPC4536 harboured no plasmids. Each of the strains possessed specific genes not present in the other two analysed strains. The three strains differed in their abundance of sugar-converting genes, and in the types of sugars that could be used as energy sources. Genes involved in the metabolism of sugars not usually connected with the dairy niche, such as myo-inositol and pullulan were also detected, but strains did not utilise these sugars. The genetic content of the three strains differed in regard to specific genes for arginine and sulfur-containing amino acid metabolism and genes contributing to resistance to heavy metal ions. In addition, variability in the presence of phage remnants and phage protection systems was evident.
conclusionsThe findings presented in this study confirm a considerable level of heterogeneity of Lactobacillus paracasei strains, even between strains isolated from the same niche.
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