ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Cortical responses to dynamic emotional facial expressions generalize across stimuli, and are sensitive to task-relevance, in adults with and without Autism.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Fusiform face area development correlates with development in higher-order social brain regions.Developmental cognitive neuroscience · 2026Article
- Social inference brain networks in autistic adults during movie-viewing: functional specialization and heterogeneity.Molecular autism · 2025Article
- Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype.Translational psychiatry · 2024Article
- Challenging the Classical View: Recognition of Identity and Expression as Integrated Processes.Brain sciences · 2023Article
- Video-evoked fMRI BOLD responses are highly consistent across different data acquisition sites.Human brain mapping · 2022Article
- PyMVPD: A Toolbox for Multivariate Pattern Dependence.Frontiers in neuroinformatics · 2022Article
- Preferential responses to faces in superior temporal and medial prefrontal cortex in three-year-old children.Developmental cognitive neuroscience · 2021Article
- Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Emotional face processing across neurodevelopmental disorders: a dynamic faces study in children with autism spectrum disorder, attention deficit hyperactivity disorder and obsessive-compulsive disorder.Translational psychiatry · 2020Article
- Visual Perception in Autism Spectrum Disorder: A Review of Neuroimaging Studies.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2020Article
- Dorsal-movement and ventral-form regions are functionally connected during visual-speech recognition.Human brain mapping · 2020Article
- Development of brain networks for social functions: Confirmatory analyses in a large open source dataset.Developmental cognitive neuroscience · 2019Article
- Intact neural representations of affective meaning of touch but lack of embodied resonance in autism: a multi-voxel pattern analysis study.Molecular autism · 2019Article
- The social neuroscience of mentalizing: challenges and recommendations.Current opinion in psychology · 2018Review
- Use and Usefulness of Dynamic Face Stimuli for Face Perception Studies-a Review of Behavioral Findings and Methodology.Frontiers in psychology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with Autism Spectrum Disorders (ASD) report difficulties extracting meaningful information from dynamic and complex social cues, like facial expressions. The nature and mechanisms of these difficulties remain unclear. Here we tested whether that difficulty can be traced to the pattern of activity in "social brain" regions, when viewing dynamic facial expressions. In two studies, adult participants (male and female) watched brief videos of a range of positive and negative facial expressions, while undergoing functional magnetic resonance imaging (Study 1: ASD n = 16, control n = 21; Study 2: ASD n = 22, control n = 30). Patterns of hemodynamic activity differentiated among facial emotional expressions in left and right superior temporal sulcus, fusiform gyrus, and parts of medial prefrontal cortex. In both control participants and high-functioning individuals with ASD, we observed (i) similar responses to emotional valence that generalized across facial expressions and animated social events; (ii) similar flexibility of responses to emotional valence, when manipulating the task-relevance of perceived emotions; and (iii) similar responses to a range of emotions within valence. Altogether, the data indicate that there was little or no group difference in cortical responses to isolated dynamic emotional facial expressions, as measured with fMRI. Difficulties with real-world social communication and social interaction in ASD may instead reflect differences in initiating and maintaining contingent interactions, or in integrating social information over time or context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.