Evidence map›Paper›PMID 29554539›Full record

ArticleCancer epidemiology2018

Circulating inflammatory proteins and gallbladder cancer: Potential for risk stratification to improve prioritization for cholecystectomy in high-risk regions.

Jill Koshiol, Yu-Tang Gao, Amanda Corbel, Troy J Kemp, Ming-Chang Shen, Allan Hildesheim, Ann W Hsing, Asif Rashid, Bingsheng Wang, Ruth M Pfeiffer and 1 more

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In one paragraph

Article in Cancer epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Gallbladder cancer.Nature reviews. Disease primers · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Chile Biliary Longitudinal Study: A Gallstone Cohort.American journal of epidemiology · 2021
    Article
  17. Review
  18. Article
  19. Association of circulating inflammation proteins and gallstone disease.Journal of gastroenterology and hepatology · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Jill KoshiolInfections Immunoepidemiology Branch, Division of Cancer Epidemiology Genetics, National Cancer Institute, MD, USA. Electronic address: koshiolj@mail.nih.gov.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Amanda CorbelInfections Immunoepidemiology Branch, Division of Cancer Epidemiology Genetics, National Cancer Institute, MD, USA.
Troy J KempHPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos, Biomedical Research, Inc, Frederick, MD, USA.
Ming-Chang ShenDepartment of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China.
Allan HildesheimInfections Immunoepidemiology Branch, Division of Cancer Epidemiology Genetics, National Cancer Institute, MD, USA.
Ann W HsingStanford Cancer Institute, Stanford School of Medicine, Palo Alto, CA, USA; Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA.
Asif RashidDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bingsheng WangDepartment of General Surgery, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai, China.
Ruth M PfeifferBiostastitics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, USA.
Ligia A PintoHPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos, Biomedical Research, Inc, Frederick, MD, USA.
National Cancer Institute · USLeidos (United States) · USFudan University · CNFudan University Shanghai Cancer Center · CNShanghai Cancer Institute · CNStanford Medicine · USThe University of Texas MD Anderson Cancer Center · US

Funding

Etiology of Biliary Tract CancerZIACP010218 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KOSHIOL, JILL · 2011 to 2025
$30.4M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010218
6 · The paper itself

Abstract

backgroundInflammatory proteins could help identify individuals most likely to have gallbladder cancer (GBC) among those waiting for cholecystectomy.

methodsWe analyzed 49 circulating inflammation-related proteins in 144 patients with GBC and 150 patients with gallstones. We calculated age- and sex-adjusted odds ratios (ORs) and 95% CIs for protein quantiles and GBC versus gallstones. Using proteins associated with early GBC (stage 1-2) that were selected in stepwise logistic regression, we created an inflammation score and explored the potential utility for risk stratification.

results26 proteins (53%) had P values for the trend across categories ≤0.001, with associations for a one category increase ranging from 1.52 (95% CI: 1.20-1.94) for CC motif ligand 4 to 4.00 (95% CI: 2.76-5.79) for interleukin (IL)-8. Soluble tumor necrosis factor receptor 2 (sTNFR2), IL-6, sTNFR1, CC motif ligand 20 (CCL20), vascular cell adhesion molecule 1, IL-16, and granulocyte colony-stimulating factor had P values ≤0.001 for early GBC. Of those, IL-6, IL-16, CCL20, and STNFR1 were included in the inflammation score. In a high-risk setting with a pre-test disease risk of 10% (e.g., elderly patients) and using an inflammation score cutoff that provides 90% sensitivity, 39% of patients on the waiting list would be predicted to be positive, and 23% of those would be predicted to have GBC.

conclusionThese results highlight the strong associations of inflammatory proteins with GBC risk and their potential clinical utility. Larger studies are needed to identify the most effective combinations of inflammatory proteins for detecting early GBC and precursor lesions.

Indexed as

AdultAgedCholecystectomyFemaleGallbladder NeoplasmsGallstonesHumansMaleMiddle AgedOdds RatioChemokinesCytokinesGallbladder cancerInflammationRisk stratification

Identifiers

PMID29554539
PMCPMC5971138
OpenAlexW2792957919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.