ArticleProceedings of the National Academy of Sciences of the United States of America1987
Expression of c-mos RNA in germ cells of male and female mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 155 citations in OpenAlex.
- Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas.Developmental biology · 2013Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Article
- How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor.Cell division · 2007Article
- A novel family of serine/threonine kinases participating in spermiogenesis.The Journal of cell biology · 1997Article
- Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.Molecular and cellular biology · 1997Article
- Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells.Molecular and cellular biology · 1995Article
- Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes.Molecular and cellular biology · 1995Article
- Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis.Cell and tissue research · 1995Article
- Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse.The EMBO journal · 1994Article
- Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.The EMBO journal · 1992Article
- The 'second-codon rule' and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.The EMBO journal · 1992Article
- Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.The EMBO journal · 1992Article
- Identification of a negative regulatory element that inhibits c-mos transcription in somatic cells.Molecular and cellular biology · 1992Article
- c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site.Molecular and cellular biology · 1991Article
- The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.Molecular and cellular biology · 1991Article
- The role of non-ras transforming genes in chemical carcinogenesis.Environmental health perspectives · 1991Review
- Methylation patterns of testis-specific genes.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have investigated the cell types in mouse testis and ovary in which the c-mos protooncogene is normally transcribed. Blot hybridization analysis of electrophoretically fractionated RNAs from testes of mice with defects in germ-cell development and from prepubertal and adult mice indicated that c-mos was transcribed during male germ-cell development. Analysis of purified populations of spermatogenic cell types detected c-mos RNA in the earliest haploid postmeiotic germ cell, the round spermatid, indicating that c-mos was expressed transiently during spermatogenesis. c-mos RNA was detected by blot hybridization in the ovaries of prepubertal mice and decreased in relative concentration following gonadotropin-stimulated proliferation of granulosa cells. These results suggested that c-mos was transcribed in oocytes and were confirmed by detection of high levels of c-mos RNA in isolated grown oocytes. Thus, c-mos is expressed in both male and female germ cells, suggesting possible roles for this protooncogene in meiosis, germ-cell development, fertilization, and early embryogenesis.
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