ArticleNature biotechnology2018
Linear assembly of a human centromere on the Y chromosome.
Article in Nature biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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The trial behind it
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Who cites it
122 citing papers in PubMed.
- Detection of single nucleotide and copy number variants in the Fabry disease-associated GLA gene using nanopore sequencing.Scientific reports · 2021Trial
- A telomere-to-telomere reference genome assembly of the Hypomesus nipponensis.Scientific data · 2026Article
- Cascading 58mer Alpha Satellite superHOR in Complete Orangutan Y Chromosome.International journal of molecular sciences · 2025Article
- A haplotype-resolved view of human gene regulation.bioRxiv : the preprint server for biology · 2025Article
- An optimized toolkit for high-molecular-weight DNA extraction and ultra-long-read nanopore sequencing using glass beads and hexamminecobalt(III) chloride.Genome research · 2025Article
- Establishing genome sequencing and assembly for non-model and emerging model organisms: a brief guide.Frontiers in zoology · 2025Review
- A near telomere-to-telomere genome assembly of the Jinhua pig: enabling more accurate genetic research.GigaScience · 2025Article
- NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads.Genome biology · 2024Article
- Assessing methylation detection for primary human tissue using Nanopore sequencing.bioRxiv : the preprint server for biology · 2024Article
- Genome assemblies forFrontiers in genetics · 2024Article
- De novo genome assembly depicts the immune genomic characteristics of cattle.Nature communications · 2023Article
- The complete and fully-phased diploid genome of a male Han Chinese.Cell research · 2023Article
- The complete sequence of a human Y chromosome.Nature · 2023Article
- Centromeric and pericentric transcription and transcripts: their intricate relationships, regulation, and functions.Chromosoma · 2023Review
- Evolutionary analysis of a complete chicken genome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome assembly composition of the String "ACGT" array: a review of data structure accuracy and performance challenges.PeerJ. Computer science · 2023Article
- Chromosome-level genome assembly of goose provides insight into the adaptation and growth of local goose breeds.GigaScience · 2022Article
- Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.Nature communications · 2022Article
- INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing.Genome biology · 2022Article
- High-Throughput Separation of Long DNA in Deterministic Lateral Displacement Arrays.Micromachines · 2022Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres. We implemented a nanopore sequencing strategy to generate high-quality reads that span hundreds of kilobases of highly repetitive DNA in a human Y chromosome centromere. Combining these data with short-read variant validation, we assembled and characterized the centromeric region of a human Y chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.