Evidence map›Paper›PMID 29553520›Full record

ArticleJournal of visualized experiments : JoVE2018

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes.

Chao Tian, Wei Zhang, Van Phuc Nguyen, Xueding Wang, Yannis M Paulus

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Molecular and cellular imaging of the eye.Biomedical optics express · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. TowardsIEEE transactions on radiation and plasma medical sciences · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chao TianKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan.
Wei ZhangDepartment of Biomedical Engineering, University of Michigan; Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College.
Van Phuc NguyenKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan.
Xueding WangDepartment of Biomedical Engineering, University of Michigan; Department of Radiology, University of Michigan.
Yannis M PaulusKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan; Department of Biomedical Engineering, University of Michigan; ypaulus@med.umich.edu.

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James D Weiland · 1987 to 2026
$17.6M
Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
NEI NIH HHS K12 EY022299NEI NIH HHS P30 EY007003
6 · The paper itself

Abstract

Photoacoustic ocular imaging is an emerging ophthalmic imaging technology that can noninvasively visualize ocular tissue by converting light energy into sound waves and is currently under intensive investigation. However, most reported work to date is focused on the imaging of the posterior segment of the eyes of small animals, such as rats and mice, which poses challenges for clinical human translation due to small eyeball sizes. This manuscript describes a novel photoacoustic microscopy (PAM) and optical coherence tomography (OCT) dual-modality system for posterior segment imaging of the eyes of larger animals, such as rabbits. The system configuration, system alignment, animal preparation, and dual-modality experimental protocols for in vivo, noninvasive, label-free chorioretinal imaging in rabbits are detailed. The effectiveness of the method is demonstrated through representative experimental results, including retinal and choroidal vasculature obtained by the PAM and OCT. This manuscript provides a practical guide to reproducing the imaging results in rabbits and advancing photoacoustic ocular imaging in larger animals.

Indexed as

AnimalsPhotoacoustic TechniquesRabbitsRetinaTomography, Optical Coherence

Identifiers

PMID29553520
PMCPMC5912387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.