ArticleJournal of visualized experiments : JoVE2018
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration.
Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Animal models of delirium: a narrative review.Translational psychiatry · 2026Review
- Intermittent Fasting Alleviates Anesthesia/Surgery-Induced Delirium-Like Behavior in Aged Mice by Remodeling Gut Microbiota.CNS neuroscience & therapeutics · 2026Article
- From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium.Journal of clinical medicine · 2025Review
- Nicotinamide Prevents the Plasticity Impairments and the Cognitive Dysfunction Caused by Bone Fracture in Older Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice.PNAS nexus · 2025Article
- Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling.Cell communication and signaling : CCS · 2024Article
- Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model.Journal of neuroinflammation · 2024Article
- The impact of age and sex on the inflammatory response during bone fracture healing.JBMR plus · 2024Article
- ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.Journal of inflammation research · 2024Article
- The P38MAPK/ATF2 signaling pathway is involved in PND in mice.Experimental brain research · 2024Article
- Article
- β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.Journal of neuroinflammation · 2023Article
- Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.Aging cell · 2022Article
- Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.Frontiers in aging neuroscience · 2022Article
- Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.Frontiers in molecular neuroscience · 2022Article
- Dietary Choline Protects Against Cognitive Decline After Surgery in Mice.Frontiers in cellular neuroscience · 2021Article
- Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction.Frontiers in aging neuroscience · 2021Review
- Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton.Methods in molecular biology (Clifton, N.J.) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Surgery is commonly used to improve and maintain quality of life. Unfortunately, in vulnerable patients such as the elderly, complications may occur and significantly diminish the outcome. Indeed, after routine orthopedic surgery to repair a fracture, as many as 50% of elderly patients suffer from neurologic complications like delirium. Also, the capacity to heal and regenerate tissue after surgery decreases with age, and can impact the quality of fracture repair and even osseous integration of implants. Thus, a better understanding of mechanisms that drive these age-dependent changes could provide strategic targets to minimize risk for such complications and optimize outcomes. Here, we introduce a clinically relevant mouse model of tibial fracture. The postoperative changes in these mice mimic some of the cognitive impairments commonly observed after routine orthopedic surgery in humans. Briefly, an incision is performed in the right hind limb under strictly aseptic conditions. Muscles are disassociated, and a 0.38-mm stainless steel pin is inserted into the upper crest of the tibia, inside the intramedullary canal. Osteotomy is then performed, and the wound is stapled. We have used this model to investigate the effects of surgical trauma on postoperative neuroinflammation and behavioral changes. By applying this fracture model in combination with parabiosis, a surgical model in which 2 mice are anastomosed, we have studied cells and secreted factors that systemically rejuvenate organ function and tissue regeneration after injury. By following our step-by-step protocol, these models can be reproduced with high fidelity, and can be adapted to interrogate many biologic pathways that are altered by surgical trauma.
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