Evidence map›Paper›PMID 29553368›Full record

ArticleeLife2018

A transcription factor collective defines the HSN serotonergic neuron regulatory landscape.

Carla Lloret-Fernández, Miren Maicas, Carlos Mora-Martínez, Alejandro Artacho, Ángela Jimeno-Martín, Laura Chirivella, Peter Weinberg, Nuria Flames

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 73 citations in OpenAlex.

  1. Fertility reversibly modulatesbioRxiv : the preprint server for biology · 2026
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  2. Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  4. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
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  5. Identity and functions of monoaminergic neurons in the predatory nematodebioRxiv : the preprint server for biology · 2025
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  8. Almost 40 years of studying homeobox genes in C. elegans.Development (Cambridge, England) · 2024
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  9. Review
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  13. A single neuron inbioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Floral Homeotic Factors: A Question of Specificity.Plants (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Carla Lloret-Fernández *Developmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
Miren Maicas *Developmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
Carlos Mora-Martínez *Developmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
Alejandro ArtachoDepartamento de Genómica y Salud, Centro Superior de Investigación en Salud Pública, FISABIO, Valencia, Spain.
Ángela Jimeno-MartínDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
Laura ChirivellaDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
Peter WeinbergDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University Medical Center, New York, United States.
Nuria FlamesDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.ORCID http://orcid.org/0000-0003-0961-0609
Instituto de Biomedicina de Valencia · ESFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHoward Hughes Medical Institute · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
European Research Council ERC Stg 2011-281920NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cell differentiation is controlled by individual transcription factors (TFs) that together activate a selection of enhancers in specific cell types. How these combinations of TFs identify and activate their target sequences remains poorly understood. Here, we identify the

Indexed as

Gene Expression ProfilingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationHEK293 CellsHumansMice, Inbred C57BLPhylogenySerotonergic NeuronsTranscription FactorsCaenorhabditis elegans ProteinsTranscription FactorsC. eleganscis-regulatory logicdevelopmental biologymouseneuronal differentiationneuroscienceserotonergic neuronsstem cellstranscription factors

Identifiers

PMID29553368
PMCPMC5916565
OpenAlexW2789282125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.