Evidence map›Paper›PMID 29553156›Full record

ArticleLab on a chip2018

3D-printed Quake-style microvalves and micropumps.

Yuan-Sheng Lee, Nirveek Bhattacharjee, Albert Folch

Abstract read
In one paragraph

Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuan-Sheng LeeDepartment of Mechanical Engineering, University of Washington, USA. ysleetw@uw.edu.ORCID 0000-0001-8411-4504
Nirveek BhattacharjeeDepartment of Bioengineering, University of Washington, USA.ORCID 0000-0003-3401-2651
Albert FolchDepartment of Bioengineering, University of Washington, USA.ORCID 0000-0002-8490-1038

Funding

Microfluidic Device to Profile Chemosensitivity in Glioma Slice CulturesR01CA181445 · NCI · UNIVERSITY OF WASHINGTON · PI FOLCH, ALBERT · 2014 to 2025
$5.3M
NCI NIH HHS R01 CA181445
6 · The paper itself

Abstract

Here we demonstrate a 3D-printable microvalve that is transparent, built with a biocompatible resin, and has a simple architecture that can be easily scaled up into large arrays. The open-at-rest valve design is derived from Quake's PDMS valve design. We used a stereolithographic (SL) 3D printer to print a thin (25 or 10 μm-thick) membrane (1200 or 500 μm-diam.) that is pneumatically pressed (∼3-6 psi) over a bowl-shaped seat to close the valve. We used poly(ethylene diacrylate) (MW = 258) (PEG-DA-258) as the resin because it yields transparent cytocompatible prints. Although the flexibility of PEG-DA-258 is inferior to that of other microvalve fabrication materials such as PDMS, the valve benefits from the bowl design and the membrane's high restoring force since it does not need a negative pressure to re-open. We also 3D-printed a micropump by combining three Quake-style valves in series. The micropump only requires positive pressure for its operation and profits from the fast return to the valves' open states. Moreover, we printed a 64-valve array constructed with 500 μm-diam. valves to demonstrate the reliability and scalability of the valves. Overall, we demonstrate the 3D-printing of compact microvalves and micropumps using a process that precludes the need for specialized, time-consuming labor.

Indexed as

Computer-Aided DesignEquipment DesignMicrofluidic Analytical TechniquesPrinting, Three-Dimensional

Identifiers

PMID29553156
PMCPMC7307877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.