ArticlePhysics in medicine and biology2018
The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Pooled it
- Histotripsy-mediated reactive oxygen species generation in vitro.Ultrasonics · 2026Article
- Changes in bubble-cloud dissolution throughout the application of histotripsy pulses.Physical review applied · 2025Article
- MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.Magnetic resonance in medicine · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Experimental & numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials.Journal of the mechanical behavior of biomedical materials · 2024Article
- Article
- (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.PloS one · 2022Article
- Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.Physics in medicine and biology · 2021Article
- Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation.IEEE transactions on bio-medical engineering · 2021Article
- Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.Ultrasound in medicine & biology · 2020Article
- Modeling tissue-selective cavitation damage.Physics in medicine and biology · 2019Article
- In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.Physics in medicine and biology · 2019Article
- Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.Physics in medicine and biology · 2019Article
- For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.Ultrasound in medicine & biology · 2019Review
- Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.BioMed research international · 2019Review
- The influence of gas diffusion on bubble persistence in shock-scattering histotripsy.The Journal of the Acoustical Society of America · 2018Article
Corrections and comments
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1 author.
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Abstract
Histotripsy is a form of therapeutic ultrasound that liquefies tissue mechanically via acoustic cavitation. Bubble expansion is paramount in the efficacy of histotripsy therapy, and the cavitation dynamics are strongly influenced by the medium elasticity. In this study, an analytic model to predict histotripsy-induced bubble expansion in a fluid was extended to include the effects of medium elasticity. Good agreement was observed between the predictions of the analytic model and numerical computations utilizing highly nonlinear excitations (shock-scattering histotripsy) and purely tensile pulses (microtripsy). No bubble expansion was computed for either form of histotripsy when the elastic modulus was greater than 20 MPa and the peak negative pressure was less than 50 MPa. Strain in the medium due to the expansion of a single bubble was also tabulated. The viability of red blood cells was calculated as a function of distance from the bubble wall based on empirical data of impulsive stretching of erythrocytes. Red blood cells remained viable at distances further than 44 µm from the bubble wall. As the medium elasticity increased, the distance over which bubble expansion-induced strain influenced red blood cells was found to decrease sigmoidally. These results highlight the relationship between tissue elasticity and the efficacy of histotripsy. In addition, an upper medium elasticity limit was identified, above which histotripsy may not be effective for tissue liquefaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.