ArticleJournal of clinical research in pediatric endocrinology2018
Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria
Article in Journal of clinical research in pediatric endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Euthyroid Sick Syndrome (ESS) and Monocyte-to-Lymphocyte Ratio (MLR) Are Predictors of Complications in Geriatric Hip Fractures: A Single-Center Retrospective Analysis.Journal of clinical medicine · 2026Article
- Thyroid Function Test Abnormalities in Human Immunodeficiency Virus Positive Patients on Antiretroviral Therapy at Matyazo Health Center, Huye, Rwanda.Rwanda journal of medicine and health sciences · 2025Article
- The Relationship Between Vitamin D and Euthyroid Sick Syndrome in Hospitalized Solid Cancer Patients: A Retrospective Study.Clinical Medicine Insights. Oncology · 2025Article
- Analysis of the Incidence of Euthyroid Sick Syndrome in Comprehensive Intensive Care Units and Related Risk Factors.Frontiers in endocrinology · 2021Article
- NovelJournal of clinical research in pediatric endocrinology · 2020Article
- Thyroid hormones concentration in portal and peripheral blood in patients with pancreatic cancer: Preliminary study.Cancer biomarkers : section A of Disease markers · 2020Observational
- Nonthyroidal Illness Syndrome Across the Ages.Journal of the Endocrine Society · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.
methodsEighty newly diagnosed children were included in the study. ESS was assessed in two different ways. According to criteria 1 ESS was present if free triiodothyronine (fT3) was below the lower limit and free thyroxine was within the normal or low limits, thyroid-stimulating hormone (TSH) was in the normal range. According to criteria 2, in addition to the above, it was required that reverse triiodothyronine (rT3) be performed and was higher than normal limits.
resultsThree of our pediatric patients had subclinical hypothyroidism and two had subclinical hyperthyroidism. Out of 75 patients, ESS was identified in 14 (17.3%) according to criteria 1 and in eight (10.6%) according to criteria 2. Only fT3 levels were significantly different in the ESS (+) and ESS (-) groups (p<0.05) according to criteria 1. A significantly negative correlation between interleukin (IL)-6 and fT3 was found, according to both sets of criteria. tumor necrosis factor alpha was negatively correlated with fT3 levels only in the criteria 1 group. There were no correlations between IL-1β and fT3, free thyroxine, rT3 and TSH levels.
conclusionESS may occur in childhood cancer and thyroid function testing should be performed routinely when cancer is diagnosed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.