ArticlePsychological medicine2019
Reduced immunity to measles in adults with major depressive disorder.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Immune response to vaccination in adults with mental disorders: A systematic review.Journal of affective disorders · 2022Pooled it
- Outcomes associated with different vaccines in individuals with bipolar disorder and impact on the current COVID-19 pandemic- a systematic review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022Pooled it
- Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial.The American journal of psychiatry · 2025Trial
- Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration.Science advances · 2025Article
- Vaccine-preventable hospitalisations in adult mental health service users: a population study.Psychological medicine · 2023Article
- Non-SARS Coronaviruses in Individuals with Psychiatric Disorders.Current topics in behavioral neurosciences · 2023Article
- Effect of Cytomegalovirus Infection on the Central Nervous System: Implications for Psychiatric Disorders.Current topics in behavioral neurosciences · 2023Article
- Therapeutic Implications of the Microbial Hypothesis of Mental Illness.Current topics in behavioral neurosciences · 2023Review
- The Relationship between Mental Disorders and the COVID-19 Pandemic-Course, Risk Factors, and Potential Consequences.International journal of environmental research and public health · 2022Review
- Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity.Immunity & ageing : I & A · 2022Review
- The Fear of Contagion and the Attitude Toward the Restrictive Measures Imposed to Face COVID-19 in Italy: The Psychological Consequences Caused by the Pandemic One Year After It Began.Frontiers in psychology · 2022Article
- Validation and Psychometric Evaluation of the Italian Version of the Fear of COVID-19 Scale.International journal of mental health and addiction · 2022Article
- Psychometric Evaluation of the Fear of COVID-19 Scale Among Chinese Population.International journal of mental health and addiction · 2022Article
- A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder.Molecular psychiatry · 2021Article
- A hidden menace? Cytomegalovirus infection is associated with reduced cortical gray matter volume in major depressive disorder.Molecular psychiatry · 2021Article
- COVID-19 vaccination for people with severe mental illness: why, what, and how?The lancet. Psychiatry · 2021Review
- Psychometric properties of the Fear of COVID-19 Scale amongst black South African university students.African journal of psychological assessment · 2021Article
- Adaptation and psychometric evaluation of Hungarian version of the Fear of COVID-19 Scale.PloS one · 2021Article
- The kynurenine pathway: a finger in every pie.Molecular psychiatry · 2020Review
- Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder.JAMA psychiatry · 2019Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundDepression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypothesis that individuals with adolescent or adult onset mood disorders would display compromised immunity to measles, a target of childhood vaccination.
methodsIgG antibodies to measles were quantified using a solid phase immunoassay in volunteers with bipolar disorder (BD, n = 64, mean age of onset = 16.6 ± 5.6), currently depressed individuals with major depressive disorder (cMDD, n = 85, mean age of onset = 17.9 ± 7.0), remitted individuals with a history of MDD (rMDD, n = 82, mean age of onset = 19.2 ± 8.6), and non-depressed comparison controls (HC, n = 202), all born after the introduction of the measles vaccine in the USA in 1963.
resultsRelative to HC, both the cMDD group (p = 0.021, adjusted odds ratios (OR) = 0.47, confidence interval (CI) = 0.24-0.90), and the rMDD group (p = 0.038, adjusted OR = 0.50, CI = 0.26-0.97) were less likely to test seropositive for measles. Compared with unmedicated MDD participants, currently medicated MDD participants had a longer lifetime duration of illness and were less likely to test seropositive for measles.
conclusionsIndividuals with adolescent or adult onset MDD are less likely to test seropositive for measles. Because lower IgG titers are associated with increased risk of measles infection, MDD may increase the risk and severity of infection possibly because of impaired maintenance of vaccine-related protection from measles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.