Evidence map›Paper›PMID 29552675›Full record

ArticleCurrent opinion in physiology2018

Cardiac pathophysiology in response to environmental stress: a current review.

Vineeta Tanwar, Aashish Katapadi, Jeremy M Adelstein, Jacob A Grimmer, Loren E Wold

Abstract read
In one paragraph

Article in Current opinion in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Guidelines for in vivo models of developmental programming of cardiovascular disease risk.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vineeta TanwarDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Aashish KatapadiMedical Student Research Program, The Ohio State University College of Medicine, Columbus, OH.
Jeremy M AdelsteinDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Jacob A GrimmerDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.
Loren E WoldDorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH.

Funding

Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0M
Muscle function and depression-like behavior in a mouse model of cancer fatigueR01NR012618 · NINR · OHIO STATE UNIVERSITY · PI REISER, PETER J, WOLD, LOREN EUGENE · 2012 to 2016
$2.2M
Defining the Impact of E-Cigarettes on Cardiac PathophysiologyR01HL139348 · NHLBI · OHIO STATE UNIVERSITY · PI WOLD, LOREN EUGENE · 2017 to 2020
$1.9M
Synergistic effects of obesity and air pollution on cardiac functionR01ES019923 · NIEHS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WOLD, LOREN EUGENE · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL139348NIA NIH HHS R01 AG057046NIEHS NIH HHS R01 ES019923NINR NIH HHS R01 NR012618
6 · The paper itself

Abstract

purposeEnvironmental stressors are disturbing our ecosystem at an accelerating rate. An increasingly relevant stressor are air pollutants, whose levels are increasing worldwide with threats to human health. These air pollutants are associated with increased mortality and morbidity from cardiovascular diseases. In this review we discuss environmental stressors focusing mainly on the various types of air pollutants, their short-term and long-term cardiovascular effects, and providing the epidemiological evidence associated with adverse cardiovascular outcomes. Direct and indirect pathophysiological mechanisms are also linked with cardiovascular complications such as thrombosis, fibrinolysis, hypertension, ischemic heart diseases and arrhythmias.

resultsEvidence to date suggests that humans are constantly being exposed to unhealthy levels of environmental toxicants with the potential of serious health conditions. Environmental stressors adversely affect the cardiovascular system and pose an increased risk for cardiovascular diseases for those who reside in highly polluted areas.

conclusionPeople with existing risk factors and those with established cardiovascular disease have increased susceptibility to environmental stressors. The literature reviewed in this article thus support public health policies aimed at reducing pollutant exposure to benefit public health.

Indexed as

cardiovascular mortalityenvironmental stressheartinflammationoxidative stressParticulate matter

Identifiers

PMID29552675
PMCPMC5851460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.