ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Temporal unfolding of declining episodic memory on the Free and Cued Selective Reminding Test in the predementia phase of Alzheimer's disease: Implications for clinical trials.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Genetic background and multidomain interventions in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Trial
- Speech-based digital biomarkers for early etiological stratification of Alzheimer's disease and frontotemporal degeneration: a biomarker-confirmed prospective study.The journal of prevention of Alzheimer's disease · 2026Article
- Stages of objective memory impairment are associated with accelerated brain aging.Scientific reports · 2026Article
- Misfolded Proteins and Cognitive Decline: Mechanistic Insights into Neurodegenerative Disorders.Neurology international · 2026Review
- Episodic memory in aging: neurocognitive bases and clinical implications of the distinction between hippocampal and frontal patterns.Dementia & neuropsychologia · 2026Review
- Misclassification in memory modification ineLife · 2025Article
- Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.Alzheimer's research & therapy · 2025Article
- Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome.Journal of intellectual disability research : JIDR · 2025Article
- The memory binding test in a longitudinal study of cognitive aging and preclinical disease.Neuropsychology · 2024Article
- Comparison of the Diagnostic Accuracy of Five Cognitive Screening Tests for Diagnosing Mild Cognitive Impairment in Patients Consulting for Memory Loss.Journal of clinical medicine · 2024Article
- The effects of musicality on brain network topology in the context of Alzheimer's disease and memory decline.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The memory binding test can anticipate Alzheimer's disease diagnosis at an early preclinical stage: a longitudinal study in the INSIGHTpreAD cohort.Frontiers in aging neuroscience · 2024Article
- Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals.Neurology · 2023Article
- The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset.European journal of neurology · 2023Article
- Compensatory Mechanisms in Early Alzheimer's Disease and Clinical Setting: The Need for Novel Neuropsychological Strategies.Journal of Alzheimer's disease reports · 2023Review
- Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2023Article
- New Therapeutics in Alzheimer's Disease Longitudinal Cohort study (NTAD): study protocol.BMJ open · 2022Article
- Memory markers in the continuum of the Alzheimer's clinical syndrome.Alzheimer's research & therapy · 2022Article
- Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study.Neurology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
introductionFree and Cued Selective Reminding Test (FCSRT) performance identifies patients with preclinical disease at elevated risk for developing Alzheimer's dementia, predicting diagnosis better than other memory tests.
methodsBased on literature mapping FCSRT performance to clinical outcomes and biological markers, and on longitudinal preclinical data from the Baltimore Longitudinal Study of Aging, we developed the Stages of Objective Memory Impairment (SOMI) model. Five sequential stages of episodic memory decline are defined by Free Recall (FR) and Total Recall (TR) score ranges and years prior to dementia diagnosis. We sought to replicate the SOMI model using longitudinal assessments of 142 Einstein Aging Study participants who developed AD over 10 years.
resultsTime to diagnosis was at least seven years if FR was intact, at least four years if TR was intact, and two years if TR was impaired, consistent with SOMI model predictions. The SOMI identified incipient dementia with excellent sensitivity and specificity. DISCUSSION: The SOMI model provides an efficient approach for clinical trial cognitive screening in advance of more costly biomarker studies and ultimately in clinical practice, and provides a vocabulary for understanding AD biomarker patterns and for re-analysis of existing clinical trial data.
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