ArticleSchizophrenia research. Cognition2018
Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial.
Article in Schizophrenia research. Cognition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation Across Mental Disorders: A Systematic Review and Dose-Response Meta-Analysis.JAMA network open · 2024Pooled it
- Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Schizophrenia bulletin · 2022Pooled it
- A meta-analytic review of transcranial direct current stimulation (tDCS) on general psychopathology symptoms of schizophrenia; immediate improvement followed by a return to baseline.Psychiatry research · 2022Pooled it
- Non-Invasive Brain Stimulation Does Not Improve Working Memory in Schizophrenia: A Meta-Analysis of Randomised Controlled Trials.Neuropsychology review · 2021Pooled it
- Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis.Psychological medicine · 2020Pooled it
- Transcranial direct current stimulation and cognitive training in the treatment of cognitive deficit in schizophrenia: a randomized controlled trial.BMC psychiatry · 2026Trial
- Working-memory effects of prefrontal tDCS across baseline cognitive-severity groups in schizophrenia: A secondary analysis of a randomized double-blind sham-controlled trial.Schizophrenia research. Cognition · 2026Article
- Adjunct Bifrontal Transcranial Direct Current Stimulation in Improving Cognitive Insight and Working Memory Deficits in Schizophrenia: A Single-blind, Randomised Sham-controlled Trial.Annals of neurosciences · 2025Article
- Transcranial direct current stimulation and its effect on cognitive symptoms of schizophrenia: An updated review.Schizophrenia research. Cognition · 2025Review
- A potential mechanism for tau protein modulating in schizophrenia with transcranial direct current stimulation intervention: A randomized controlled trial.BioImpacts : BI · 2025Article
- Pre-clinical indications of brain stimulation treatments for non-affective psychiatric disorders, a status update.Translational psychiatry · 2023Review
- Personalized Brain-Computer Interface and Its Applications.Journal of personalized medicine · 2022Review
- A Literature Mini-Review of Transcranial Direct Current Stimulation in Schizophrenia.Frontiers in psychiatry · 2022Review
- Impact of Psychosocial Occupational Therapy Combined with Anodal Transcranial Direct Current Stimulation to the Left Dorsolateral Prefrontal Cortex on the Cognitive Performance of Patients with Schizophrenia: A Randomized Controlled Trial.Hong Kong journal of occupational therapy : HKJOT · 2021Article
- Transcranial direct current stimulation and emotion processing deficits in psychosis and depression.European archives of psychiatry and clinical neuroscience · 2021Review
- Potential Locations for Non-Invasive Brain Stimulation in Treating Schizophrenia: A Resting-State Functional Connectivity Analysis.Frontiers in neurology · 2021Article
- A Multimodal Neuroprosthetic Interface to Record, Modulate and Classify Electrophysiological Biomarkers Relevant to Neuropsychiatric Disorders.Frontiers in bioengineering and biotechnology · 2021Article
- [Brain stimulation for the selective treatment of schizophrenia symptom domains : Non-invasive and invasive concepts].Der Nervenarzt · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe lack of efficacy of pharmacological treatments for cognitive and negative symptoms in schizophrenia highlights the need for new interventions. We investigated the effects of tDCS on working memory and negative symptoms in patients with schizophrenia.
methodDouble-blinded, randomized, sham-controlled clinical trial, investigating the effects of 10 sessions of tDCS in schizophrenia subjects. Stimulation used 2 mA, for 20 min, with electrodes of 25 cm
resultsWe did not find group ∗ time interaction for the working memory (
conclusionThe results from this trial highlight the therapeutic effects of tDCS for treatment of persistent symptoms in schizophrenia, with reduction of negative symptoms. We were not able to confirm the superiority of active tDCS over sham to improve working memory performance. Larger sample size studies are needed to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.