Evidence map›Paper›PMID 29552508›Full record

ArticleSchizophrenia research. Cognition2018

Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.

Rose Mary Xavier, Jennifer R Dungan, Richard S E Keefe, Allison Vorderstrasse

Abstract read
In one paragraph

Article in Schizophrenia research. Cognition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  12. Evidence of an interaction betweenEuropean psychiatry : the journal of the Association of European Psychiatrists · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rose Mary XavierNeuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 1034 Gates Pavilion, HUP, 3400 Spruce Street, Philadelphia, PA 19104, United States.
Jennifer R DunganDuke University School of Nursing, United States.
Richard S E KeefePsychiatry and Behavioral Sciences, Duke University School of Medicine, United States.
Allison VorderstrasseNYU Rory Meyers College of Nursing, United States.

Funding

Replication of Schizophrenia Associations in CATIER01MH074027 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2006 to 2007
$715k
NIMH NIH HHS R01 MH074027
6 · The paper itself

Abstract

Genetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also examined if schizophrenia associated autosomal loci were associated with specific symptoms or cognitive domains. Case-only analysis using data from the Clinical Antipsychotics Trials of Intervention Effectiveness-Schizophrenia trials (

Identifiers

PMID29552508
PMCPMC5852279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.